姜黃素是姜黃中一種小分子多酚化合物，是姜黃發(fā)揮生物活性的最主要成分，具有抗炎、抗氧化、抗病毒、抗腫瘤等廣泛的藥理作用。近年來，非編碼RNA（ncRNA）作為姜黃素潛在的治療靶點被廣泛研究。姜黃素可通過ncRNA影響調(diào)控腫瘤細胞增殖、凋亡和遷移的關(guān)鍵信號通路或直接作用于相關(guān)蛋白進而發(fā)揮抗腫瘤作用。綜述了姜黃素參與調(diào)控微小RNA（miRNA）、長鏈非編碼RNA（LncRNA）和環(huán)狀RNA（circRNA）發(fā)揮抗腫瘤作用的情況，希望對姜黃素的抗腫瘤研究提供參考依據(jù)。

Curcumin is a kind of small molecular polyphenol compound in Curcumae Longae Rhizoma, which is the most important component in Curcumae Longae Rhizoma to exert biological activity, and has a wide range of pharmacological effects, such as anti-inflammatory, antioxidant, antiviral, and anti-tumor, etc. In recent years, non-coding RNA (ncRNA) has been widely studied as a potential therapeutic target of curcumin. Curcumin can play an anti-tumor role by influencing the key signal pathway regulating the proliferation, apoptosis, and migration of tumor cells through ncRNA or directly acting on related proteins. This paper reviews anti-tumor activity of curcumin in regulating microRNA (miRNA), long-chain non-coding RNA (LncRNA) and circular RNA (circRNA), hoping to provide reference for the anti-tumor research of curcumin.

天津市教委科研計劃項目（2021KJ126）