骨折后的愈合狀態(tài)直接影響患者的生活質(zhì)量，如何提高骨折患者骨愈合效果是亟待解決的問題。穿心蓮內(nèi)酯是穿心蓮中主要活性成分，可能通過促進(jìn)成骨細(xì)胞增殖，抑制核因子κB（NF-κB）信號通路激活，激活Wnt/β-連環(huán)蛋白（Wnt/β-catenin）信號通路，調(diào)節(jié)護(hù)骨素/細(xì)胞核因子κB受體活化因子配基（OPG/RANKL）信號通路，調(diào)節(jié)成骨基因表達(dá)產(chǎn)物，改善軟骨細(xì)胞功能，抑制雌激素相關(guān)受體α（ERRα）信號通路等多途徑促使骨愈合?？偨Y(jié)了穿心蓮內(nèi)酯促進(jìn)骨折骨愈合作用及其作用機(jī)制，希望為穿心蓮內(nèi)酯的臨床使用提供依據(jù)。

Healing state after fracture directly affects the quality of life of patients, and how to improve the bone healing effect of fracture patients is an urgent problem to be solved. Andrographolide is the main active component in Andrographis Herba, which may promote osteoblast proliferation, inhibit the activation of NF-κB signaling pathway, activate Wnt/β-catenin signaling pathway, regulate OPG/RANKL signaling pathway, regulate the expression product of osteoblast gene, improves the function of chondrocytes, inhibit estrogen related receptors α signal path, and other multiple ways to promote bone healing. This article summarized the effect and its mechanism of andrographolide in promoting bone healing of fracture, hoping to provide evidence based support for the clinical use of andrographolide.

R977