動(dòng)脈粥樣硬化是一種慢性血管炎性疾病，內(nèi)皮功能障礙是動(dòng)脈粥樣硬化病變的關(guān)鍵早期階段。淫羊藿苷是從淫羊藿中分離出的類黃酮成分，具有多種藥理作用，能減輕內(nèi)皮細(xì)胞氧化損傷和細(xì)胞凋亡、抑制內(nèi)皮-間充質(zhì)轉(zhuǎn)化進(jìn)程、抑制平滑肌細(xì)胞增殖和遷移、阻止泡沫細(xì)胞形成、抑制炎癥反應(yīng)、調(diào)控多種miRNA的表達(dá)，從多種途徑發(fā)揮抗動(dòng)脈粥樣硬化的作用。總結(jié)了淫羊藿苷抗動(dòng)脈粥樣硬化的作用機(jī)制，希望為淫羊藿苷的臨床應(yīng)用提供參考。

Atherosclerosis is a chronic vasculitis disease, and endothelial dysfunction is the key early stage of atherosclerosis. Icariin is a flavonoid component isolated from Epimedii Folium, which has various pharmacological effects. Icariin can alleviate the oxidative damage and apoptosis of endothelial cells, inhibit the process of endothelial mesenchymal transformation, inhibit the proliferation and migration of smooth muscle cells, prevent the formation of foam cells, reduce inflammatory reaction, regulate the expression of multiple miRNAs, and thus play the role of against atherosclerosis in various ways. This article summarized the mechanism of icariin against atherosclerosis, hoping to provide reference for the clinical application of icariin.

R972

國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（2018YFC1707100）；廣東省重點(diǎn)領(lǐng)域研發(fā)計(jì)劃（2020B111112002）