目的 優(yōu)選廣藿香揮發(fā)油β-環(huán)糊精包合物制備的高速剪切包合工藝。方法 在單因素考察的基礎(chǔ)上，以收得率、包合率的綜合評(píng)分為評(píng)價(jià)指標(biāo)，采用G1-熵權(quán)法結(jié)合星點(diǎn)設(shè)計(jì)-響應(yīng)面法，對(duì)剪切轉(zhuǎn)速、剪切時(shí)間、β-環(huán)糊精與揮發(fā)油質(zhì)量比例進(jìn)行考察。通過(guò)Design-Expert 8.0.6.1軟件分析各因素的交互作用優(yōu)選最佳工藝參數(shù)。結(jié)果 采用高速剪切法制備廣藿香揮發(fā)油β-環(huán)糊精包合物的最佳包合工藝條件為：β-環(huán)糊精與揮發(fā)油質(zhì)量比例8∶1，剪切時(shí)間3 min，剪切轉(zhuǎn)速4 200 r/min，β-環(huán)糊精與水質(zhì)量比例1∶7。結(jié)論 優(yōu)化了廣藿香揮發(fā)油β-環(huán)糊精包合物的高速剪切法制備的最佳工藝參數(shù)，為后續(xù)相關(guān)產(chǎn)品的開(kāi)發(fā)研究和生產(chǎn)提供指導(dǎo)。

Objective To optimize the preparation process of Pogostemon cablin volatile oil β-cyclodextrin inclusion. Methods On the basis of single factor investigation, G1-entropy weight method combined with central composite design and response surface method was used. Shear speed, shear time, and the ratio of β-cyclodextrin to volatile oil were investigated with the comprehensive score of yield rate and inclusion rate as evaluation indexes. The interaction of various factors was analyzed by Design-Expert 8.0.6.1 software, and the optimized preparation process was investigated. Results The optimal inclusion process of high speed shear inclusion process was as follows:the ratio of β-cyclodextrin to volatile oil was 8:1, the shear time was 3 min, the shear speed was 4200 r/min, and the ratio of β-cyclodextrin to water was 1:7. Conclusion The optimized inclusion process of Pogostemon cablin volatile oil β-cyclodextrin inclusion is optimized, and can provide guidance for the development and production of related products in the future.

R284.2

佛山應(yīng)急科技攻關(guān)專項(xiàng)（2020001000206）；佛山市科技創(chuàng)新項(xiàng)目（2120001002309）