骨折是威脅人類身體健康的重要疾病之一，骨折愈合除了與骨折本身的損傷程度有關(guān)以外，還與骨折端血液循環(huán)、內(nèi)分泌、骨吸收/骨形成平衡、雌激素等因素有關(guān)。柚皮苷是骨碎補(bǔ)中活性成分，是一種二氫類黃酮化合物，具有多種藥理活性，能夠促進(jìn)成骨細(xì)胞增殖和分化，促進(jìn)新生血管形成，增強(qiáng)雌激素受體α的活性，促進(jìn)骨保護(hù)素的分泌，抑制核因子-κB信號(hào)通路激活，激活Ras信號(hào)通路，形成復(fù)合材料，通過多種機(jī)制或途徑促進(jìn)骨折愈合。綜述了柚皮苷促進(jìn)骨折愈合的作用機(jī)制研究進(jìn)展，希望為柚皮苷的臨床使用提供參考。

Fracture is one of the important diseases threatening human health. Fracture healing is not only related to the degree of injury of the fracture itself, but also related to blood circulation at the fracture end, endocrine, bone absorption/bone formation balance, estrogen, and other factors. Naringin is an effective component in Drynariae Rhizoma, and it is a dihydroflavonoid compound with a variety of pharmacological activities. Naringin can promote the proliferation and differentiation of osteoblasts, promote neovascularization, enhance the activity of estrogen receptor α, promote the secretion of osteoprotegerin, inhibit the activation of NF-κB signaling pathway, activate Ras signaling pathway, and form composite materials to promote fracture healing through a variety of mechanisms or pathways. This article reviews the research progress on naringin in promoting fracture healing, hoping to provide reference for the clinical use of naringin.

R966

山東省中醫(yī)藥科技發(fā)展計(jì)劃項(xiàng)目（2017-429）