目的 探討小兒肺熱咳喘顆粒聯(lián)合阿莫西林克拉維酸鉀顆粒治療小兒支原體肺炎的臨床效果。方法 選取2020年8月—2022年8月無錫市第九人民醫(yī)院就診的92例小兒支原體肺炎患兒，采用奇偶數(shù)法將患兒分為對照組和治療組，每組各46例。對照組患兒口服阿莫西林克拉維酸鉀顆粒，25 mg/kg，1次/12 h。治療組患兒在對照組基礎(chǔ)上開水沖服小兒肺熱咳喘顆粒，3 g/次，3周歲以下患兒3次/d，3周歲以上患兒4次/d。兩組患兒均連續(xù)治療10 d。觀察兩組的臨床療效，比較兩組的臨床癥狀消失時(shí)間、血清炎癥因子。結(jié)果 治療后，治療組的總有效率95.65%明顯高于對照組80.43%，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，治療組發(fā)熱、咳嗽、肺部干濕啰音消失時(shí)間均明顯短于對照組，差異具有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，兩組血清白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）水平均明顯下降（P＜0.05），且治療組血清IL-6、TNF-α、CRP水平明顯低于對照組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。結(jié)論 小兒肺熱咳喘顆粒聯(lián)合阿莫西林克拉維酸鉀治療小兒支原體肺炎可明顯提高療效，加快患兒臨床癥狀消失，有效減輕體內(nèi)炎癥反應(yīng)，具有良好的安全性。

Objective To explore clinical effect of Xiao'er Feire Kechuan Granules combined with Amoxicillin and Clavulanate Potassium Granules in treatment of mycoplasma pneumonia in children. Methods Children (92 cases) with mycoplasma pneumonia in Wuxi Ninth People's Hospital from August 2020 to August 2022 were divided into control and treatment groups according to the odd even number method, and each group had 46 cases. Children in the control group were po administered with Amoxicillin and Clavulanate Potassium Granules, 25 mg/kg, once every 12 h. Children in the treatment group were po administered with Xiao'er Feire Kechuan Granules on the basis of the control group, 3 g/time, under 3 years old, three times daily, over 3 years old, four times daily. Children in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the clinical symptom disappearance time, and serum inflammatory factors in two groups were compared. Results After treatment, the total effective rate (95.65%) of the treatment group was significantly higher than 80.43% of the control group, with a statistically significant difference (P < 0.05). After treatment, the disappearance time of fever, cough, and lung dry and wet rales in the treatment group was significantly shorter than that in the control group, with a statistically significant difference (P < 0.05). After treatment, the serum levels of IL-6, TNF-α, and CRP in two groups were significantly decreased (P < 0.05), and the serum levels of IL-6, TNF-α, and CRP in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiao'er Feire Kechuan Granules combined with Amoxicillin and Clavulanate Potassium Granules in treatment of mycoplasma pneumonia in children can significantly improve the efficacy, accelerate the disappearance of clinical symptoms in children, effectively reduce inflammation in vivo, with good safety.

R974