目的 探討當(dāng)歸苦參丸聯(lián)合克林霉素磷酸酯凝膠治療玫瑰痤瘡的臨床療效。方法 選擇2019年11月—2022年8月天津市北辰醫(yī)院收治120例玫瑰痤瘡者，隨機(jī)分為對(duì)照組（60例）和治療組（60例）。對(duì)照組患者外涂克林霉素磷酸酯凝膠，2次/d。在對(duì)照組的基礎(chǔ)上，治療組口服當(dāng)歸苦參丸，6 g/次，2次/d。兩組服藥8周。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀緩解時(shí)間，皮膚病生活質(zhì)量量表（DLQI），血清炎性因子腫瘤壞死因子-α（TNF-α）、抗菌肽-37（LL-37）、白細(xì)胞介素-6（IL-6）和干擾素-γ（INF-γ）水平及不良反應(yīng)情況。結(jié)果 治療后，治療組患者臨床有效率為98.33%，明顯高于對(duì)照組（83.33%，P＜0.05）。治療后，治療組患者癥狀緩解時(shí)間均早于對(duì)照組（P＜0.05）。治療后，兩組患者DLQI評(píng)分均明顯下降（P＜0.05），且治療組的DLQI評(píng)分低于對(duì)照組（P＜0.05）。治療后，兩組患者LL-37、IL-6、TNF-α水平均低于治療前，而IFN-γ水平高于治療前（P＜0.05），且治療組血清炎性因子水平明顯好于對(duì)照組（P＜0.05）。治療后，治療組不良反應(yīng)發(fā)生率（5.00%）明顯低于對(duì)照組（11.67%，P＜0.05）。結(jié)論 當(dāng)歸苦參丸聯(lián)合克林霉素磷酸酯凝膠治療玫瑰痤瘡效果確切，可顯著改善癥狀，有效降低炎性反應(yīng)。

Objective To observe the clinical efficacy of Danggui Kushen Pills combined with Clindamycin Phosphate Gel in treatment of rosacea. Methods Patients (120 cases) with rosacea in Tianjin Beichen Hospital from November 2019 to August 2022 were randomly divided into control (60 cases) and treatment (60 cases) group. Patients in the control group were coated with Clindamycin Phosphate Gel, twice daily. Patients in the treatment group were po administered with Danggui Kushen Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, and the relief time of symptom, scoring ratio of dermatosis quality of life, serum inflammatory factor LL-37, IL-6, TNF-α and IFN-γ levels, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 98.33%, which was significantly higher than that of the control group (83.33%, P < 0.05). After treatment, the time of symptom relief in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the DLQI score in two groups were significantly decreased (P < 0.05), and the DLQI score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the levels of LL-37, IL-6 and TNF-α in two groups were lower than those before treatment, while the level of IFN-γ was higher (P < 0.05), and the level of serum inflammatory factors in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group (5.00%) was significantly lower than that in the control group (11.67%, P < 0.05). Conclusion Clindamycin Phosphate Gel combined with Danggui Kushen Pills is effective in treatment of roseacne, which can significantly improve the symptoms and effectively reduce the inflammatory reaction.

R986