目的 探討氟米龍聯(lián)合曲安奈德治療治療過敏性結(jié)膜炎的臨床療效。方法 選取2021年7月—2022年10月桂林醫(yī)學(xué)院第二附屬醫(yī)院眼科及貴港愛爾眼科收治的70例過敏性結(jié)膜炎患者，隨機(jī)分為對照組（35例）和治療組（35例）。對照組患者給予氟米龍滴眼液，2滴/次，3次/d。在對照組的基礎(chǔ)上，治療組結(jié)膜下注射曲安奈德注射液，10 mg/0.25 mL，1次/d，共2次。兩組患者用藥7 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀好轉(zhuǎn)時間，血清炎性因子P物質(zhì)（SP）、干擾素-γ（IFN-γ）、白細(xì)胞介素-17（IL-17）、胸腺基質(zhì)淋巴細(xì)胞生成素（TSLP）水平及不良反應(yīng)發(fā)生情況。結(jié)果 治療后，治療組患者總有效率（97.14%）明顯高于對照組（80.03%，P＜0.05）。治療后，治療組眼睛癢、結(jié)膜充血、流淚、結(jié)膜囊分泌物增多好轉(zhuǎn)時間均短于對照組（P＜0.05）。治療后，兩組血清炎性因子IL-17、SP、TSLP水平低于治療前，而IFN-γ水平高于治療前（P＜0.05），且治療組這些血清炎性因子水平明顯好于對照組（P＜0.05）。結(jié)論 氟米龍聯(lián)合曲安奈德治療過敏性結(jié)膜炎效果確切，能較快好轉(zhuǎn)癥狀，有效降低炎性因子水平。

Objective To investigate the therapeutic effect of fluorometholone combined with triamcinolone acetonide in treatment of allergic conjunctivitis. Methods Patients (70 cases) with allergic conjunctivitis in the Second Affiliated Hospital Guilin Medical University and Eye Ophthalmology Hospital (Guigang) from Junly 2021 to October 2022 were randomly divided into control (35 cases) and treatment (35 cases) group. Patients in the control group were administered with Fluorometholone Eye Drops, 2 drops/time, three times daily. Patients in the treatment group were subconjunctival injected with Triamcinolone Acetonide Injection on the basis of the control group, 10 mg/0.25 mL, once daily for two times. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, the serum IL-17, SP, TSLP, and IFN-γ levels, and complications in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.14%) was significantly higher than that of the control group (80.03%, P < 0.05). After treatment, the improvement time of itchy eyes, conjunctival congestion, tears, conjunctival sac secretion increased in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-17, SP and TSLP in two groups were lower than those before treatment, while the level of IFN-γ was significantly increased (P < 0.05), and the level of serum inflammatory factors in the treatment group was significantly better than that in the control group (P < 0.05). Conclusion Triamcinolone acetonide combined with Fluorometholone Eye Drops is effective in treatment of allergic conjunctivitis, which can quickly improve the symptoms and effectively reduce the level of inflammatory factors.

R988.1

廣西醫(yī)療衛(wèi)生適宜技術(shù)開發(fā)與推廣應(yīng)用項(xiàng)目（S2020107）