目的 探討齒痛消炎靈顆粒聯(lián)合米諾環(huán)素軟膏治療慢性根尖周炎的臨床療效。方法 選取2020年6月—2022年11月唐山市人民醫(yī)院收治的82例慢性根尖周炎患者，共90顆患牙，根據(jù)隨機(jī)數(shù)字表法將所有患者分為對(duì)照組（41例，46顆患牙）和治療組（41例，44顆患牙）。對(duì)照組使用米諾環(huán)素軟膏進(jìn)行封閉治療，米諾環(huán)素軟膏注入注射針后，將針尖接近根尖孔，將藥物注滿根管內(nèi)，待注滿溢出后使用氧化鋅丁香油黏固粉封閉，每周1次。治療組患者在對(duì)照組基礎(chǔ)上口服齒痛消炎靈顆粒，10 g/次，3次/d。兩組患者連續(xù)4周。觀察兩組的臨床療效，比較患牙的牙齦指數(shù)、菌斑指數(shù)，對(duì)比兩組患者生活質(zhì)量的變化，以及滲出液中炎癥因子白細(xì)胞介素-10（IL-10）、白細(xì)胞介素-1β（IL-1β）、白細(xì)胞介素-34（IL-34）水平。結(jié)果 治療后，治療組總有效率為93.18%，明顯高于對(duì)照組總有效率76.09%，組間比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，兩組的牙齦指數(shù)、菌斑指數(shù)明顯降低（P＜0.05），且治療組的牙齦指數(shù)、菌斑指數(shù)明顯低于對(duì)照組（P＜0.05）。治療后，兩組的口腔健康影響程度（OHIP-14）評(píng)分明顯降低（P＜0.05），且治療組的OHIP-14評(píng)分明顯低于對(duì)照組（P＜0.05）。治療后，兩組的滲出液IL-10、IL-1β、IL-34水平低于治療前（P＜0.05），治療組的滲出液IL-10、IL-1β、IL-34水平明顯低于對(duì)照組（P＜0.05）。結(jié)論 齒痛消炎靈顆粒聯(lián)合米諾環(huán)素軟膏能提高慢性根尖周炎的療效，減輕患者的牙周癥狀，提高患者生活質(zhì)量，減輕炎癥反應(yīng)，并且安全性良好。

Objective To investigate the clinical effect of Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment in treatment of chronic periapical inflammation. Methods Patients (82 cases, 90 affected teeth) with chronic periapical inflammation in Tangshan People's Hospital from June 2020 to November 2022 were divided into the control group (41 cases, 46 affected teeth) and the treatment group (41 cases, 44 affected teeth) according to the random number table method. Patients in the control group were treated with Minocycline Hydrochloride Ointment for sealing treatment. After injecting Minocycline Hydrochloride Ointment into the injection needle, the needle tip was placed close to the apical hole, and the drug was filled into the root canal. After filling up and overflowing, zinc oxide clove oil cement powder was used to seal, once weekly. Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the gingival index and plaque index, the changes in quality of life, the levels of IL-10, IL-1β, and IL-34 in the exudate in two groups were compared. Results After treatment, the total effective rate in the treatment group was 93.18%, significantly higher than the total effective rate in the control group of 76.09%, and the difference between two groups was statistically significant (P < 0.05). After treatment, the gingival index and plaque index of two groups were significantly decreased (P < 0.05), and the gingival index and plaque index of the treatment group were significantly lower than those of the control group (P < 0.05). After treatment, the OHIP-14 scores in two groups were significantly lower (P < 0.05), and the OHIP-14 scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of IL-10, IL-1β, and IL-34 in the exudates of the two groups were lower than those before treatment (P < 0.05), and the levels of IL-10, IL-1β, and IL-34 in the exudates of the treatment group were significantly lower than those of the control group (P < 0.05). Conclusion Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment can improve the efficacy of chronic periapical inflammation, reduce periodontal symptoms, reduce inflammatory response, improve the quality of life of patients, and the drug safety is reasonable.

R988.2

河北省衛(wèi)生健康委醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20181210）