[關(guān)鍵詞]
[摘要]
心血管疾病是危害人們健康的最主要的疾病之一。中藥多糖可改善心肌缺血再灌注損傷、心肌梗死、動脈粥樣硬化、心肌肥厚等多種心血管疾病，其保護機制為通過激活或抑制核因子-κB、磷脂酰肌醇3-激酶/蛋白激酶B、內(nèi)質(zhì)網(wǎng)應激、核因子E2相關(guān)因子2等多種信號通路，進而發(fā)揮抗氧化應激、抗炎、抗內(nèi)質(zhì)網(wǎng)應激、抗細胞凋亡和調(diào)節(jié)能量代謝紊亂作用來實現(xiàn)對心血管疾病的保護?？偨Y(jié)了中藥多糖防治心血管疾病的作用機制，以期為預防和治療心血管疾病提供參考。
[Key word]
[Abstract]
Cardiovascular disease is one of major diseases endangering people's health. Traditional Chinese medicine polysaccharides can improve myocardial ischemia reperfusion injury, myocardial infarction, atherosclerosis, myocardial hypertrophy, and other cardiovascular diseases. The protective mechanism of traditional Chinese medicine polysaccharides on cardiovascular disease is through regulating NF-κB, Nrf2, PI3K/Akt, and other signaling pathways, and then play the role of anti-oxidative stress, anti-inflammation, anti-endoplasmic reticulum stress, anti-apoptosis, and relieve energy metabolism disorder to achieve. This article summarized the mechanism of Chinese herbal polysaccharides in preventing and treating cardiovascular disease, hoping to provide reference for Chinese herbal polysaccharides in prevention and treatment of cardiovascular disease.
[中圖分類號]
R285.5
[基金項目]
國家重點研發(fā)計劃（2022YFC3501800）；國家自然科學基金資助項目（81973624）；國家中醫(yī)藥管理局中醫(yī)藥創(chuàng)新團隊及人才支持計劃項目（ZYYCXTD-C-202203）
