[關(guān)鍵詞]
[摘要]
骨關(guān)節(jié)炎是一種全球常見的炎癥性疾病，目前臨床治療骨關(guān)節(jié)炎的方法以緩解骨關(guān)節(jié)炎疼痛、抑制炎癥的對(duì)癥治療方案為主。漆黃素屬于黃酮類物質(zhì)，具有多種生理活性，可以促進(jìn)衰老細(xì)胞凋亡，抑制血管新生，阻斷軟骨下骨與軟骨的異常串?dāng)_，調(diào)節(jié)炎性因子，保護(hù)軟骨細(xì)胞免受氧化應(yīng)激。綜述了漆黃素治療骨關(guān)節(jié)炎的作用機(jī)制，為深入開展漆黃素治療骨關(guān)節(jié)炎的基礎(chǔ)研究以及新型藥物的開發(fā)提供依據(jù)。
[Key word]
[Abstract]
Osteoarthritis is a common inflammatory disease in the world. At present, the clinical treatment of osteoarthritis is mainly symptomatic treatment to alleviate the pain and inflammation of osteoarthritis. Fisetin is a flavonoid substance, which has various physiological activities. Fisetin can promote apoptosis of aging cells, inhibit angiogenesis, block abnormal crosstalk between subchondral bone and cartilage, regulate inflammatory factors, and protect chondrocytes from oxidative stress. This article reviews the mechanism of fisetin in treatment of osteoarthritis, and provides a basis for further basic research on fisetin in treatment of osteoarthritis and the development of new drugs.
[中圖分類號(hào)]
R285.5；R982
[基金項(xiàng)目]
國家中醫(yī)藥管理局中醫(yī)藥循證能力建設(shè)項(xiàng)目（2019XZZX-GK006）；天津市教委科研計(jì)劃項(xiàng)目（2019KJ064）；天津市名中醫(yī)傳承工作室建設(shè)項(xiàng)目（881022）
