妊娠期糖尿病是糖尿病中的特殊類型，尋找療效確切、作用多樣的治療藥物成為臨床研究的熱點(diǎn)。葛根素是由葛根中提取的活性成分，已被證明可以預(yù)防各種病理生理過程，包括糖尿病及其并發(fā)癥等。葛根素可以通過降低胰島素抵抗，降低細(xì)胞凋亡、保護(hù)胰島素β細(xì)胞功能，增強(qiáng)機(jī)體抗氧化活性，提升降糖效果而發(fā)揮降糖作用。探討了葛根素防治妊娠糖尿病的作用機(jī)制，為指導(dǎo)妊娠糖尿病的臨床治療提供參考。

Gestational diabetes mellitus is a special type of diabetes, and finding effective and multi acting therapeutic drugs has become a hot topic in clinical research. Puerarin is an active ingredient extracted from Puerariae Lobatae Radix, which has been proved to prevent various pathophysiological processes, including diabetes and its complications. Puerarin can reduce insulin resistance, reduce cell apoptosis and protect the function of insulin β cells, enhancing the body's antioxidant activity, and improve the hypoglycemic effect. This article discusses the mechanism of puerarin in prevention and treatment of gestational diabetes mellitus, and provides a reference for guiding the clinical treatment of gestational diabetes mellitus.

R285.5；R977

廊坊市科技支撐計(jì)劃項(xiàng)目（2020013069）