婦科腫瘤嚴(yán)重威脅女性的生命健康,目前婦科腫瘤的治療仍以手術(shù)和放療為主,并使用化療藥預(yù)防復(fù)發(fā)和轉(zhuǎn)移。小檗堿為季銨生物堿,具有廣泛的生物活性。小檗堿能夠抑制腫瘤細(xì)胞生長(zhǎng)、增殖,抑制腫瘤細(xì)胞遷移、侵襲,誘導(dǎo)腫瘤細(xì)胞凋亡,并增加化療藥敏感性。總結(jié)了小檗堿抗乳腺癌、卵巢癌、宮頸癌、子宮內(nèi)膜癌等婦科腫瘤作用機(jī)制的研究進(jìn)展,以期將小檗堿開(kāi)發(fā)為防治婦科腫瘤的新藥提供參考。

Gynecological tumors pose a serious threat to women's lives and health. At present, the treatment of gynecological tumors is still mainly surgery and radiotherapy, and chemotherapy drugs are used to prevent recurrence and metastasis. Berberine is a quaternary ammonium alkaloid with a wide range of pharmacological activities. Berberine can inhibit the growth and proliferation of tumor cells, inhibit the migration and invasion of tumor cell migration, induce apoptosis of tumor cells, and increase the sensitivity of chemotherapy drugs. This article summarized the research progress on mechanism of berberine against gynecological tumors, such as breast carcinoma, ovarian carcinoma, cervical carcinoma, endometrial carcinoma, etc., in order to provide reference for the development of berberine as a new drug for the prevention and treatment of gynecological tumors.

R285.5；R977