目的 探討銀杏酮酯滴丸聯(lián)合鹽酸貝尼地平片治療冠心病心絞痛的臨床療效。方法 選取2020年2月-2023年1月武警特色醫(yī)學(xué)中心收治的68例冠心病心絞痛患者，根據(jù)計(jì)算機(jī)隨機(jī)排列法將所有患者分為對照組和治療組，每組各34例。對照組患者口服鹽酸貝尼地平片，2片/次，1次/d。治療組在對照組基礎(chǔ)上口服銀杏酮酯滴丸，8丸/次，3次/d。兩組患者連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組的心絞痛發(fā)作頻率、每次發(fā)作持續(xù)時(shí)間、心絞痛程度、心功能指標(biāo)以及血清中CD105、金屬基質(zhì)蛋白酶-3（MMP-3）、同型半胱氨酸（Hcy）、脂蛋白磷脂酶（Lp-PLA2）、肌鈣蛋白T （cTnT）水平。結(jié)果 治療后，治療組的總有效率94.12%比對照組的總有效率76.47%高（P<0.05）。治療后，兩組的心絞痛發(fā)作頻率、每次發(fā)作持續(xù)時(shí)間明顯低于治療前（P<0.05），且治療組心絞痛發(fā)作頻率、每次發(fā)作持續(xù)時(shí)間較對照組更低（P<0.05）。治療后，兩組的視覺模擬評分法（VAS）評分顯著降低（P<0.05），治療組VAS評分較對照組降低更明顯（P<0.05）。治療后，兩組的心排血量（CO）、左心室射血分?jǐn)?shù)（LVEF）高于治療前（P<0.05），且治療組CO、LVEF較對照組更高（P<0.05）。治療后，兩組的CD105水平高于治療前，MMP-3、Hcy水平低于治療前（P<0.05）；治療后，治療組的CD105水平高于對照組，MMP-3、Hcy水平低于對照組（P<0.05）。治療后，兩組的脂蛋白磷脂酶（Lp-PLA2）、肌鈣蛋白T （cTnT）水平低于治療前（P<0.05）；治療后治療組的Lp-PLA2、cTNT水平低于對照組（P<0.05）。結(jié)論 銀杏酮酯滴丸聯(lián)合鹽酸貝尼地平片治療冠心病心絞痛的療效確切，能顯著提高療效，減輕心絞痛癥狀和心肌損傷。

Objective To investigate the clinical effect of Ginkgo Ketone Ester Dropping Pills combined with Benidipine Hydrochloride Tablets e in treatment of angina pectoris of coronary heart disease. Methods Patients (68 cases) with angina pectoris of coronary heart disease in Special Medical Center of Armed Police from February 2020 to January 2023 were divided into control and treatment groups according to the computer random arrangement method, and each group had 34 cases. Patients in the control group were po administered with Benidipine Hydrochloride Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Ginkgo Ketone Ester Dropping Pills on the basis of the control group, 8 pills/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the frequency and duration of angina attacks, VAS scores, CO, LVEF, the levels of CD105, MMP-3, Hcy, Lp-PLA2, and cTnT in two groups were compared. Results After treatment, the total effective rate (94.12%) of the treatment group was higher than 76.47% in the control group (P< 0.05). After treatment, the frequency and duration of angina attacks in two groups were significantly lower than before treatment (P < 0.05), and the frequency and duration of angina attacks in the treatment group were lower than those in the control group (P < 0.05). After treatment, VAS scores of two groups were significantly decreased (P < 0.05), and VAS score of the treatment group were decreased more significantly than that of the control group (P< 0.05). After treatment, CO and LVEF of two groups were higher than before treatment (P < 0.05), and CO and LVEF of the treatment group were higher than those of the control group (P < 0.05). After treatment, the levels of CD105 in two groups were higher than before treatment, while the levels of MMP-3 and Hcy were lower than before treatment (P < 0.05). After treatment, the levels of CD105 in the treatment group was higher than that in the control group, while the levels of MMP-3 and Hcy were lower than those in the control group (P < 0.05). After treatment, the levels of Lp-PLA2 and cTnT in two groups were lower than before treatment (P< 0.05). After treatment, the levels of Lp-PLA2 and cTnT in the treatment group were lower than those in the control group (P < 0.05). Conclusion Ginkgo Ketone Ester Dropping Pills combined with Benidipine Hydrochloride Tablets are effective in treatment of angina pectoris of coronary heart disease, which can significantly improve the therapeutic effect, alleviate angina symptoms and myocardial damage.

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