目的 探討補(bǔ)血益母顆粒聯(lián)合麥角新堿治療宮縮乏力性產(chǎn)后出血的臨床療效。方法 選取2021年3月-2023年3月?？谑袐D幼保健院收治的80例宮縮乏力性出血患者，隨機(jī)法分為對(duì)照組（40例）和治療組（40例）。對(duì)照組肌肉注射馬來(lái)酸麥角新堿注射液，0.2 mg/次，每日次數(shù)不超過(guò)5次。在對(duì)照組的基礎(chǔ)上，治療組口服補(bǔ)血益母顆粒，12 g/次，3次/d。兩組均完成5 d治療。觀察兩組患者臨床療效，比較治療前后兩組患者活化部分凝血活酶時(shí)間（APTT）、凝血酶時(shí)間（TT）、凝血酶原時(shí)間（PT）和纖維蛋白原（FIB）指標(biāo)水平，產(chǎn)后出血量和止血時(shí)間，及子宮體積和宮底下降高度。結(jié)果 治療后，治療組臨床有效率（97.50%）明顯高于對(duì)照組（85.00%，P<0.05）。治療后，兩組患者TT、PT、APTT指標(biāo)均低于治療前，而FIB指標(biāo)高于治療前（P<0.05），且治療組凝血功能指標(biāo)明顯好于對(duì)照組（P<0.05）。治療后，治療組患者止血時(shí)間顯著短于對(duì)照組（P<0.05），治療組30 min及2、24 h的出血量均逐漸低于對(duì)照組（P<0.05）。治療后，兩組患者子宮體積、宮底下降高度指標(biāo)均低于治療前（P<0.05），且治療組明顯低于對(duì)照組（P<0.05）。結(jié)論 補(bǔ)血益母顆粒聯(lián)合麥角新堿治療宮縮乏力性產(chǎn)后出血效果確切，可有效糾正機(jī)體凝血狀態(tài)，增強(qiáng)子宮收縮力，并同時(shí)縮短產(chǎn)后出血量，且安全有效。

Objective To explore the effects of Buxue Yimu Granules combined with ergometrine in treatment of postpartum hemorrhage caused by uterine atony. Methods Patients (80 cases) with rheumatoid arthritis in Haikou Hospital of the Maternal and Child Health from March 2021 to March 2023 were randomly divided into control (40 cases) and treatment (40 cases) group. Patients in the control group were intramuscular injection administered with Ergometrine Maleate Injection, 0.2 mg/time, no more than 5 times per day. Patients in the treatment group were po administered with Buxue Yimu Granules on the basis of the control group, 12 g/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, and the indicators of TT, PT, APTT, FIB, bleeding volume, hemostasis, uterine volume and fundus descent in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.50%) was significantly higher than that of the control group (85.00%, P < 0.05). After treatment, the indexes of TT, PT and APTT in two groups were lower than those before treatment, while the index of FIB was higher (P < 0.05), and the indexes of blood coagulation in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the hemostatic time of the treatment group was significantly shorter than that of the control group (P < 0.05), and the bleeding volume of 30 min, 2 h and 24 h in the treatment group was gradually lower than that in the control group (P < 0.05). After treatment, the uterine volume and uterine floor descending height in both groups were lower than those before treatment (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Buxue Yimu Granules combined with ergometrine in treatment of postpartum hemorrhage caused by uterine atony is effective, which can enhance uterine contractility and shorten the amount of postpartum hemorrhage. It is safe and effective.

R984

海南省自然科學(xué)基金青年項(xiàng)目（821QN395）