目的 探討復(fù)方苦參注射液聯(lián)合TP方案化療治療局部晚期宮頸癌的臨床療效。方法 選擇鄭州市第三人民醫(yī)院2016年9月-2022年10月收治的82例局部晚期宮頸癌患者，隨機分為對照組和治療組，每組各41例。對照組靜脈滴注紫杉醇注射液，135~175 mg/m²，1次/3周；同時靜脈滴注順鉑注射液，75 mg/m²。治療組在對照組治療基礎(chǔ)上靜脈滴注復(fù)方苦參注射液，30 mL加入生理鹽水250 mL，1次/d，連用14 d。21 d為1個化療療程，兩組均連續(xù)治療3個療程。觀察兩組患者臨床療效，比較治療前后兩組患者中醫(yī)證候積分和不良反應(yīng)。結(jié)果 治療后，治療組的客觀緩解率（87.80%）與對照組客觀緩解率（70.73%）相比明顯升高（P<0.05）。治療后，兩組患者陰道出血、帶下量、帶下色、帶下質(zhì)評分均低于治療前（P<0.05），且治療組明顯低于對照組（P<0.05）。治療后，治療組不良反應(yīng)發(fā)生率明顯低于對照組（P<0.05）。結(jié)論 復(fù)方苦參注射液聯(lián)合TP方案化療治療局部晚期宮頸鱗狀細胞癌的臨床療效較好，安全性和可靠性較高。

Objective To investigate the clinical effect of Compound Kushen Injection combined with TP chemotherapy regimen in treatment of local advanced cervical cancer. Methods Patients (82 cases) with local advanced cervical cancer in the Third People's Hospital of Zhengzhou from September 2016 to October 2022 were randomly divided into control and treatment group, and each group had 41 cases. Patients in the control group were iv administered with Paclitaxel Injection, 135-175 mg/m², once every three weeks, and they were iv administered with Cisplatin Injection, 75 mg/m². Patients in the treatment group were iv administered with Compound Kushen Injection on the basis of the control group, 30 mL added into normal saline 250 mL, once daily for 14 d. 21 d was one course of chemotherapy, and they were treated continuously for 3 courses. After treatment, the clinical evaluation was evaluated, and the TC syndrome scores, adverse reactions in two groups before and after treatment were compared. Results After treatment, the objective remission rate of the treatment group (87.80%) was significantly higher than that of the control group (70.73%, P < 0.05). After treatment, the scores of vaginal bleeding, subband volume, color and quality in two groups were lower than those before treatment (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Compound Kushen Injection combined with TP chemotherapy is effective, safe, and reliable in the treatment of locally advanced cervical squamous cell carcinoma.

R979.1