目的 探討活血解毒丸聯(lián)合醋酸潑尼松片治療急性乳腺炎的臨床療效。方法 選取2021年3月-2023年3月四川省婦幼保健院收治的120例急性乳腺炎患者，根據(jù)計算機隨機排列法分為對照組和治療組，每組60例。對照組口服醋酸潑尼松片，4片/次，2次/d。治療組在對照組基礎(chǔ)上溫水送服活血解毒丸，0.5袋/次，2次/d。兩組患者連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組的癥狀消退時間、主觀疼痛程度、血清因子水平。結(jié)果 治療后，治療組的總有效率（93.33%）高于對照組的總有效率（78.33%），差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組發(fā)熱、乳腺紅腫、乳腺疼痛消退時間比對照組短（P<0.05）。治療后，兩組的視覺模擬法（VAS）評分明顯低于治療前（P<0.05），且治療組患者VAS評分較對照組更低（P<0.05）。治療后，兩組的血清中血清淀粉樣蛋白A （SAA）、腫瘤壞死因子-α（TNF-α）、超敏C反應(yīng)蛋白（hs-CRP）水平低于治療前（P<0.05），且治療組的血清SAA、TNF-α、hs-CRP水平低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 活血解毒丸聯(lián)合醋酸潑尼松片可提高急性乳腺炎的臨床療效，能減輕癥狀，降低炎癥反應(yīng)。

Objective To investigate the clinical effect of Huoxue Jiedu Pills combined with Prednisone Acetate Tablets in treatment of acute mastitis. Methods Patients (120 cases) with acute mastitis in Chengdu Fifth People's Hospital from March 2021 to March 2023 were divided into control and treatment groups according to the computer random arrangement method, and each group had 60 cases. Patients in the control group were po administered with Prednisone Acetate Tablets, 4 tablets/time, twice daily. Patients in the treatment group were po administered with Huoxue Jiedu Pills on the basis of the control group, 0.5 bag/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the symptom resolution time, subjective pain level, and serum factor level in two groups were compared. Results After treatment, the total effective rate of 93.33% in the treatment group was higher than 78.33% in the control group, with a statistically significant difference (P< 0.05). After treatment, the regression times of fever, breast redness and breast pain in the treatment group were lower than that in the control group (P < 0.05). After treatment, VAS score of two groups was significantly lower than that before treatment (P < 0.05), and the VAS score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the serum levels of SAA, TNF-α, and hs-CRP in two groups were lower than before treatment (P < 0.05), and the serum levels of SAA, TNF-α, and hs-CRP in the treatment group were lower than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion Huoxue Jiedu Pills combined with Prednisone Acetate Tablets can improve the clinical efficacy of acute mastitis, reduce symptoms and inflammation.

R984

四川省衛(wèi)生和計劃生育委員會科研課題（18PJ108）