[關(guān)鍵詞]
[摘要]
2型糖尿病"多食易饑"現(xiàn)象控制難度大，大量進(jìn)食進(jìn)一步促進(jìn)病情進(jìn)展。饑餓素是空腹時(shí)由胃底細(xì)胞分泌的一種食欲調(diào)節(jié)激素，是目前已知的唯一與食欲直接相關(guān)的激素。饑餓素作為與食欲密切相關(guān)的激素，二甲雙胍、噻唑烷二酮類(lèi)藥物、α-葡萄糖苷酶抑制劑、二肽基肽酶-4（DPP-4）抑制劑、胰高血糖素樣肽-1（GLP-1）類(lèi)似物、鈉-葡萄糖共轉(zhuǎn)運(yùn)蛋白2（SGLT-2）抑制劑等2型糖尿病治療藥物均對(duì)其水平產(chǎn)生一定的影響。綜述了各類(lèi)常見(jiàn)2型糖尿病治療藥物對(duì)血漿饑餓素水平的影響，為以饑餓素作為靶點(diǎn)的2型糖尿病的防治研究提供新思路。
[Key word]
[Abstract]
It is difficult to control the phenomenon of "overeating and easy hunger" in type 2 diabetes. Eating in large quantities further promotes the progress of the disease. Ghrelin is an appetite-related hormone secreted by gastric fundus cells under fasting state, and it is the only known hormone directly related to appetite. As a hormone closely related to appetite, the level of ghrelin could be affected by type 2 diabetes drugs, such as metformin, thiazolidinediones, α-glycosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like petide-1 (GLP-1) analogues, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors. This article reviews the effects of various common therapeutic drugs for type 2 diabetes on plasma ghrelin levels, so as to provide new ideas for the prevention and treatment of type 2 diabetes with ghrelin as a target.
[中圖分類(lèi)號(hào)]
R965
[基金項(xiàng)目]
國(guó)家自然科學(xué)基金資助項(xiàng)目（81904082）
