2型糖尿病"多食易饑"現(xiàn)象控制難度大，大量進食進一步促進病情進展。饑餓素是空腹時由胃底細胞分泌的一種食欲調節(jié)激素，是目前已知的唯一與食欲直接相關的激素。饑餓素作為與食欲密切相關的激素，二甲雙胍、噻唑烷二酮類藥物、α-葡萄糖苷酶抑制劑、二肽基肽酶-4（DPP-4）抑制劑、胰高血糖素樣肽-1（GLP-1）類似物、鈉-葡萄糖共轉運蛋白2（SGLT-2）抑制劑等2型糖尿病治療藥物均對其水平產(chǎn)生一定的影響。綜述了各類常見2型糖尿病治療藥物對血漿饑餓素水平的影響，為以饑餓素作為靶點的2型糖尿病的防治研究提供新思路。

It is difficult to control the phenomenon of "overeating and easy hunger" in type 2 diabetes. Eating in large quantities further promotes the progress of the disease. Ghrelin is an appetite-related hormone secreted by gastric fundus cells under fasting state, and it is the only known hormone directly related to appetite. As a hormone closely related to appetite, the level of ghrelin could be affected by type 2 diabetes drugs, such as metformin, thiazolidinediones, α-glycosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like petide-1 (GLP-1) analogues, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors. This article reviews the effects of various common therapeutic drugs for type 2 diabetes on plasma ghrelin levels, so as to provide new ideas for the prevention and treatment of type 2 diabetes with ghrelin as a target.

R965

國家自然科學基金資助項目（81904082）