腦梗死是人類第三大死因和第一大致殘?jiān)?，如何提高防治腦梗死的療效成為社會(huì)廣泛關(guān)注的焦點(diǎn)。白藜蘆醇屬于二苯乙烯類多酚，具有廣泛的生物活性，可通過(guò)抑制炎癥反應(yīng)、抗氧化應(yīng)激反應(yīng)、增強(qiáng)細(xì)胞自噬和能量代謝、促進(jìn)突觸生長(zhǎng)、降低腦缺血區(qū)神經(jīng)細(xì)胞凋亡、保護(hù)血腦屏障的功能和結(jié)構(gòu)等途徑發(fā)揮防治腦梗死的作用。對(duì)白藜蘆醇防治腦梗死的作用機(jī)制進(jìn)行綜述，為白藜蘆醇臨床治療腦梗死提供新思路。

Cerebral infarction is the third leading cause of death and primary cause of disability in humans, and how to improve the efficacy of cerebral infarction has become a widespread focus of attention in society. Resveratrol is a kind of stilbene polyphenol, which has wide activities, and plays a role in prevention and treatment of ischemic stroke by inhibiting inflammatory response, antioxidant stress response, enhancing autophagy and energy metabolism, promoting synaptic growth, reducing neuronal apoptosis in cerebral ischemia area, and protecting the function and structure of blood-brain barrier. This article reviews mechanism of resveratrol in prevention and treatment of cerebral infarction, and provides new ideas for treatment of cerebral infarction with resveratrol.

R285.5

重慶市衛(wèi)生健康委醫(yī)學(xué)科研項(xiàng)目（2023WSJK017）