目的 探討桃紅清血丸聯(lián)合卡泊三醇治療白癜風的臨床療效。方法 選取2021年3月—2023年3月河南省中醫(yī)院收治的90例白癜風患者，隨機法分對照組（45例）和治療組（45例）。對照組患者外涂卡泊三醇軟膏，每次2 mg/cm²，2次/d。在對照組的基礎上，治療組口服桃紅清血丸，15丸/次，2次/d。兩組患者治療8周。觀察兩組患者臨床療效，比較治療前后兩組患者皮損面積好轉，皮膚病生活質量指數（DLQI）評分，血清炎性因子干擾素-γ（IFN-γ）、白細胞介素-6（IL-6）、白細胞介素-17A（IL-17A）和腫瘤壞死因子-α（TNF-α）水平。結果 治療后，治療組患者臨床有效率為97.78%，明顯高于對照組有效率（82.22%，P＜0.05）。治療2、4、8周后，治療組皮損面積好轉均小于對照組（P＜0.05）。治療后，兩組患者DLQI評分均明顯下降（P＜0.05），且治療組DLQI評分明顯低于對照組（P＜0.05）。治療后，兩組血清炎性因子IL-6、IL-17A和TNF-α水平明顯降低，而IFN-γ水平明顯升高（P＜0.05），且治療組IL-6、IL-17A、TNF-α和IFN-γ水平明顯好于對照組（P＜0.05）。結論 桃紅清血丸聯(lián)合卡泊三醇治療白癜風效果確切，可增強局部皮損血液微循環(huán)，促進皮損面積縮小，并使臨床療效提高。

Objective To explore the clinical effect of Taohong Qingxue Pills combined with carpotriol in treatment of vitiligo. Methods Patients (90 cases) with vitiligo in Henan Provincial Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were randomly divided into control (45 cases) and treatment (45 cases) group. Patients in the control group were administered with Calcipotriol Ointment, 2 mg/cm² at a time, twice daily. Patients in the treatment group were po administered with Taohong Qingxue Pills on the basis of the control group, 15 pills/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, and the improvement in skin lesion area, DLQI scores, the levels of serum IL-6, IL-17A, TNF-α and IFN-γ in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.78%, which was significantly higher than that of the control group (82.22%, P < 0.05). After 2 weeks, 4 weeks and 8 weeks of treatment, the area of skin lesions in the treatment group was smaller than that in the control group (P< 0.05). After treatment, the DLQI score in two groups was significantly decreased, and the DLQI score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-6, IL-17A and TNF-α were significantly decreased, while the level of IFN- γ was significantly increased in two groups (P< 0.05), and the levels of IL-6, IL-17A, TNF-α and IFN- γ in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic effect of carpotriol and Taohong Qingxue Pills is effective, which can enhance the blood microcirculation of local skin lesions, reduce the area of skin lesions, and improve the clinical curative effect.

R986

河南省中醫(yī)藥科學研究專項課題（2021JDZX2104）