天然化合物-O-甲基轉(zhuǎn)移酶（NPOMT）是一種以S-腺苷甲硫氨酸（SAM）為供體，靶向天然化合物中氧原子的甲基轉(zhuǎn)移酶，在體內(nèi)主要以兩種形式存在：兒茶酚-O-甲基轉(zhuǎn)移酶（COMT）、羥基吲哚-O-甲基轉(zhuǎn)移酶（HIOMT）。COMT、HIOMT代謝多種內(nèi)源性物質(zhì)（主要是鄰苯二酚類以及羥基吲哚類化合物），參與體內(nèi)信號轉(zhuǎn)導(dǎo)、生長增殖、能量代謝、節(jié)律調(diào)控等一系列生理學(xué)過程。對NPOMT的體內(nèi)分布和表達、底物、功能、在體內(nèi)的表達調(diào)控和抑制劑進行綜述，以期為用于治療相關(guān)代謝性疾病的NPOMT特異性激動劑/抑制劑的研發(fā)以及相關(guān)疾病的診斷和預(yù)后評估提供參考。

Natural product-O-methyltransferases (NPOMT) is a methyltransferase using S-adenosylmethionine (SAM) as a donor that targets the O atom in natural compounds. NPOMT exists in main two forms in the body: catechol-O-methyltransferase (COMT) and hydroxyindole-O-methyltransferase (HIOMT). COMT and HIOMT metabolizes a variety of endogenous substances (mainly catechol and hydroxy-indole compounds), and participates in a series of physiological processes such as signal transduction, growth and proliferation, energy metabolism, and rhythm regulation. This article reviews distribution and expression in vivo, substrates, functions, expression regulation in vivo, and inhibitors of NPOMT, with the aim of providing reference for the development of NPOMT specific agonists/inhibitors for treatment of related metabolic diseases, as well as for the diagnosis and prognosis evaluation of related diseases.

R977

國家自然科學(xué)基金資助項目（82173884）