肝癌是最常見的惡性腫瘤之一，也是全球癌癥相關死亡的主要原因。順鉑是臨床上治療肝癌的一線化療藥物，然而不良反應和耐藥性是順鉑治療肝癌的兩大挑戰(zhàn)，因此一些天然產(chǎn)物作為潛在的抗癌藥物和增敏劑引起了廣大學者的密切關注。中藥有效成分聯(lián)合順鉑可發(fā)揮協(xié)同增效、降低化療不良反應等作用來更好地抗肝癌。從逆轉細胞凋亡受阻、調(diào)控細胞自噬、降低化療藥物濃度、誘導DNA損傷和抑制上皮–間充質轉化5個方面綜述中藥有效成分逆轉肝癌順鉑耐藥的機制，以期為未來減輕臨床肝癌順鉑耐藥、提高肝癌患者的生存質量和治療效果提供參考。

Liver cancer is one of the most common malignancies and is the leading cause of cancer-related death worldwide. Cisplatin is a first-line chemotherapy drug for the treatment of liver cancer in clinical practice. However, adverse reactions and drug resistance are the two major challenges of cisplatin in treatment of liver cancer. Therefore, some natural products as potential anticancer drugs and sensitizers have attracted close attention from scholars. The combination of effective ingredients of traditional Chinese medicine and cisplatin can better resist liver cancer by exerting synergistic effects and reducing chemotherapy adverse reactions. This article reviews the mechanisms of effective components in traditional Chinese medicine against cisplatin-induced resistance of liver cancer from five aspects: reversing cell apoptosis obstruction, regulating cell autophagy, reducing drug concentration, inducing DNA damage, and inhibiting epithelial mesenchymal transition, to provide reference for reducing cisplatin-induced resistance against liver cancer in clinics, improving the quality of life and treatment effectiveness of liver cancer patients in the future.

R979.1

國家自然科學基金資助項目（81402344）；陜西省自然科學基礎研究計劃項目（2020JM-595，2023-JC-YB-745）