目的 探討百咳寧顆粒聯(lián)合布地奈德治療小兒百日咳綜合征的療效及其對(duì)潮氣呼吸肺功能的影響。方法 選取2020年1月—2022年12月河北省兒童醫(yī)院收治的98例百日咳綜合征患兒，采用隨機(jī)數(shù)字表法將98例百日咳綜合征患兒分為對(duì)照組和治療組，每組各49例。對(duì)照組給予吸入用布地奈德混懸液，1 mL吸入用布地奈德混懸液與2 mL生理鹽水混合，2次/d。治療組在對(duì)照組治療基礎(chǔ)上口服百咳寧顆粒，患兒年齡≤1歲，1袋/次；1歲＜年齡≤3歲，1.5袋/次；年齡＞3歲，2袋/次，3次/d。兩組患兒均連續(xù)治療10 d。觀察兩組的臨床療效，比較兩組治療前后潮氣呼吸肺功能及血清白細(xì)胞介素17（IL-17）、白細(xì)胞介素6（IL-6）、C反應(yīng)蛋白（CRP）的變化情況。結(jié)果 治療后，治療組總有效率是95.92%，顯著高于對(duì)照組的81.63%（P＜0.05）。治療后，兩組患兒公斤體質(zhì)量潮氣量、達(dá)峰容積比、達(dá)峰時(shí)間比均較同組治療前明顯上升（P＜0.05）；且治療后，治療組患兒公斤體質(zhì)量潮氣量、達(dá)峰容積比、達(dá)峰時(shí)間比顯著大于對(duì)照組（P＜0.05）。治療后，兩組患兒血清IL-17、IL-6、CRP水平均較同組治療前明顯降低（P＜0.05）；且治療后，治療組患兒血清IL-17、IL-6、CRP水平顯著低于對(duì)照組（P＜0.05）。治療過(guò)程中，對(duì)照組和治療組患者不良反應(yīng)發(fā)生率分別是4.08%、8.16%，兩組比較差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 百咳寧顆粒聯(lián)合布地奈德治療小兒百日咳綜合征安全有效，可明顯改善患兒的潮氣呼吸肺功能及呼吸道炎癥反應(yīng)，該方案可作為臨床治療小兒百日咳綜合征的選擇之一。

Objective To explore the efficacy of Baikening Granules combined with budesonide in treatment of pertussis syndrome in children and its impact on tidal breathing lung function.Methods A total of 98 children with pertussis syndrome admitted to Hebei Children’s Hospital from January 2020 to December 2022 were selected and divided into control group and treatment group by random number table method, with 49 cases in each group. Patients in the control group were given Budesonide Suspension for Inhalation, 1 mL of Budesonide Suspension for Inhalation mixed with 2 mL of normal saline, twice daily. Patients in the treatment group were po administered with Baikening Granules on the basis of the control group, children ≤1 year old, 1 bag/time; 1 year old < children ≤3 years old, 1.5 bags/time; children > 3 years old, 2 bags/time, 3 times daily. Both groups were treated continuously for 10 d. The clinical effects of two groups were observed, and the changes of tidal respiratory lung function and serum interleukin 17 (IL-17), interleukin 6 (IL-6) and C-reactive protein (CRP) before and after treatment were compared between two groups. Results After treatment, the total effective rate of treatment group was 95.92%, which was significantly higher than that of control group (81.63%, P < 0.05). After treatment, tidal volume per kilogram of body mass, peak-to-volume ratio and peak-to-time ratio in 2 groups were significantly increased compared with before treatment (P < 0.05). After treatment, the tidal volume per kg of body mass, peak-to-volume ratio and peak-to-time ratio in treatment group were significantly higher than those in control group (P < 0.05). After treatment, serum levels of IL-17, IL-6 and CRP in 2 groups were significantly lower than before treatment (P< 0.05). After treatment, the serum levels of IL-17, IL-6 and CRP in treatment group were significantly lower than those in control group (P< 0.05). In the course of treatment, the incidence of adverse reactions in control group and treatment group was 4.08% and 8.16%, respectively, and there was no statistical significance between the two groups. Conclusion Baikening Granules combined with budesonide is safe and effective in treatment of pertussis syndrome in children, and can obviously improve the moisture respiratory lung function and respiratory inflammatory response of children, which can be used as one of the options for clinical treatment of children with pertussis syndrome.

R974

河北省醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20190799）