[關(guān)鍵詞]
[摘要]
目的 探討蒲地藍(lán)消炎口服液聯(lián)合硫酸羥氯喹片治療口腔扁平苔蘚的效果。方法 選擇唐山市人民醫(yī)院在2020年11月—2023年6月收治82例口腔扁平苔蘚患者,將所有患者根據(jù)隨機數(shù)字表法分為對照組(41例)和治療組(41例)。對照組口服硫酸羥氯喹片,1片/次,2次/d。治療組在對照組基礎(chǔ)上口服蒲地藍(lán)消炎口服液,10 mL/次,3次/d。兩組持續(xù)治療4周。比較兩組的臨床療效、體征積分、疼痛程度、口腔黏膜病損面積和血清指標(biāo)。結(jié)果 治療后,治療組的總有效率(92.68%)明顯高于對照組(75.61%),差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組的體征積分、數(shù)字疼痛強度量表(NRS)評分、病損面積均明顯低于治療前(P<0.05),治療組的體征積分、NRS評分、病損面積均低于對照組(P<0.05)。治療后,兩組的血清白細(xì)胞介素-17(IL-17)、神經(jīng)生長因子(NGF)、白細(xì)胞介素-12(IL-12)水平均低于治療前(P<0.05),治療組血清IL-17、NGF、IL-12水平均低于對照組(P<0.05)。結(jié)論 蒲地藍(lán)消炎口服液聯(lián)合硫酸羥氯喹片可提高口腔扁平苔蘚的治療效果,減輕癥狀和體征,縮小病損面積,降低炎癥反應(yīng)。
[Key word]
[Abstract]
Objective To investigate the effect of Pudilan Xiaoyan Oral Liquid combined with Hydroxychloroquine Sulfate Tablets in treatment of oral lichen planus. Methods Patients (82 cases) with oral lichen planus in Tangshan People’s Hospital from November 2020 to June 2023 were divided into control and treatment groups according to the random number table method, and each group had 41 cases. Patients in the control group were po administered with Hydroxychloroquine Sulfate Tablets, 1 tablets/time, twice daily. Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies, the physical signs score, NRS scores, lesion area, and serum indexes in two groups were compared. Results After treatment, the total effective rate of the treatment group (92.68%) was significantly higher than that of the control group (75.61%), and the difference was statistically significant (P< 0.05). After treatment, the physical signs score, NRS score, and lesion area were significantly lower than those before treatment (P < 0.05), and the physical signs score, NRS score, and lesion area of the treatment group were lower than those of the control group (P < 0.05). After treatment, the serum levels of IL-17, NGF, and IL-12 in two groups were lower than those before treatment (P < 0.05), and the serum levels of IL-17, NGF, and IL-12 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Hydroxychloroquine Sulfate Tablets can improve the therapeutic effect of oral lichen planus, reduce symptoms and signs, reduce the area of lesion, and reduce inflammation.
[中圖分類號]
R988.2
[基金項目]
河北省衛(wèi)生健康委醫(yī)學(xué)科學(xué)研究課題計劃(20181210)