目的 分析石斛夜光丸聯(lián)合聚乙二醇滴眼液治療干眼的臨床療效。方法 選取2022年6月—2023年6月黑龍江中醫(yī)藥大學(xué)附屬第一醫(yī)院收治的136例干眼患者，按隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組各68例。對(duì)照組接受聚乙二醇滴眼液治療，使用前搖勻，每眼1滴/次，3次/d。治療組在對(duì)照組治療基礎(chǔ)上口服石斛夜光丸，1丸/次，2次/d。兩組療程4周。比較兩組臨床療效、熒光素染色淚膜破裂時(shí)間（FBUT）等相關(guān)臨床檢查指標(biāo)及眼表疾病指數(shù)（OSDI）量表、干眼相關(guān)生活質(zhì)量評(píng)分問卷（DEQS）、簡(jiǎn)式抑郁–焦慮–壓力量表（DASS-21）評(píng)分和淚液中轉(zhuǎn)化生長(zhǎng)因子-β2（TGF-β2）、CC趨化因子配體1（CCL1）、可溶性生長(zhǎng)刺激表達(dá)基因2蛋白（sST2）、白細(xì)胞介素（IL）-1β水平。結(jié)果 治療后，治療組總有效率是97.06%，顯著高于對(duì)照組的88.24%（P＜0.05）。治療后，兩組FBUT、SⅠt和淚河高度均顯著增加，而FL評(píng)分均顯著降低（P＜0.05）；治療后，治療組相關(guān)臨床檢查指標(biāo)改善優(yōu)于對(duì)照組（P＜0.05）。治療后，兩組OSDI評(píng)分、DEQS評(píng)分和DASS-21評(píng)分均顯著降低（P＜0.05）；且治療后，治療組OSDI評(píng)分、DEQS評(píng)分和DASS-21評(píng)分均顯著低于對(duì)照組（P＜0.05）。治療后，兩組淚液中TGF-β2均顯著升高，而淚液中CCL1、sST2、IL-1β水平均顯著降低（P＜0.05）；治療后，治療組淚液中TGF-β2、CCL1、sST2、IL-1β改善優(yōu)于對(duì)照組（P＜0.05）。結(jié)論 石斛夜光丸聯(lián)合聚乙二醇滴眼液治療干眼的效果確切，能安全有效地控制干眼，促進(jìn)眼部炎癥及眼表?yè)p傷緩解，進(jìn)一步改善患者淚膜穩(wěn)定性和淚液分泌功能，提升生活質(zhì)量及精神心理狀態(tài)，值得臨床推廣應(yīng)用。

Objective To analyze the clinical efficacy of Shihu Yeguang Pills combined with Polyethylene Glycol Eye Drops in treatment of dry eyes. Methods A total of 136 patients with dry eye treated in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from June 2022 to June 2023 were selected and divided into control group and treatment group according to random number table method, with 68 cases in each group. Patients in control group were given Polyethylene Glycol Eye Drops, shook well before use, 1 drop/eye, 3 times daily. Patients in the treatment group were po administered with Shihu Yeguang Pills on the basis of the control group, 1 pill/time, twice daily. Both groups were treated for 4 weeks. The clinical efficacy, fluorescein stained tear film break time (FBUT) and other relevant clinical examination indicators, OSDI scores, DEQS scores, DASS-21 scores, TGF-β2, CCL1, sST2, and IL-1β were compared in two groups before and after treatment were compared.Results After treatment, the total effective rate of the treatment group was 97.06%, which was significantly higher than that of the control group (88.24%, P< 0.05). After treatment, FBUT, SⅠt and lacrimal river height were significantly increased, while FL scores were significantly decreased in both groups (P < 0.05). After treatment, the improvement of relevant clinical examination indexes in the treatment group was better than that in the control group (P < 0.05). After treatment, OSDI score, DEQS score and DASS-21 score were significantly decreased in both groups (P < 0.05). After treatment, OSDI score, DEQS score and DASS-21 score in treatment group were significantly lower than those in control group (P < 0.05). After treatment, the levels of TGF-β2 in tears of both groups were significantly increased, but the levels of CCL1, sST2 and IL-1β in tears were significantly decreased (P< 0.05). After treatment, the improvement of TGF-β2, CCL1, sST2 and IL-1β in tears of the treatment group was better than that of control group (P < 0.05). Conclusion Shihu Yeguang Pills combined with Polyethylene Glycol Eye Drops has definite curative effects in treatment of dry eyes, and can safely and effectively control dry eye, promote the alleviation of ocular inflammation and ocular surface damage, further improve the stability of tear film and tear secretion function of patients, improve the quality of life and mental state, which is worthy of clinical promotion and application.

R988.1

國(guó)家自然科學(xué)基金面上項(xiàng)目（81973908）；黑龍江省中醫(yī)藥科研項(xiàng)目（ZYW2022-051、ZHY2023-126）