肝纖維化是肝臟對于各種病因所致的慢性肝損傷而引發(fā)自身愈合修復(fù)的一種反應(yīng)。目前尚無治療肝纖維化、肝硬化的有效手段和藥物。鱉甲煎丸臨床上主要用于病毒性肝炎后肝纖維化和代謝相關(guān)脂肪性肝病纖維化治療。鱉甲煎丸可調(diào)節(jié)免疫、調(diào)控相關(guān)因子、調(diào)控相關(guān)信號通路、調(diào)控細(xì)胞周期，發(fā)揮抗肝纖維化作用。總結(jié)了鱉甲煎丸抗肝纖維化作用機(jī)制的研究進(jìn)展，以期為鱉甲煎丸今后的研究方向和臨床應(yīng)用提供參考。

Liver fibrosis is a response of the liver to chronic liver injury caused by various etiologies, leading to self-healing repair. At present, there are no effective methods or drugs for treating liver fibrosis and cirrhosis. Biejia Decoction Pills are mainly used in clinical practice for treatment of post viral hepatitis liver fibrosis and metabolic related fatty liver disease fibrosis. Biejia Decoction Pills can exert its anti-liver fibrosis effect by regulating immunity, related factors, related signaling pathways, and cell cycle. This article summarizes the research progress on mechanism of anti-liver fibrosis effect of Biejia Decoction Pills, in order to provide reference for further in-depth research and clinical applications of Biejia Decoction Pills in the future.

R285

天津市教委科研計(jì)劃項(xiàng)目（2022ZD053）