[關(guān)鍵詞]
[摘要]
目的 探討婦炎消膠囊聯(lián)合甲硝唑片治療細菌性陰道病的臨床療效。方法 選取2021年1月—2023年1月鄭州市第七人民醫(yī)院就診120例的細菌性陰道病患者,按信封隨機法分成對照組(60例)和治療組(60例)。對照組口服甲硝唑片,2次/d,2片/次。治療組在對照組基礎(chǔ)上口服婦炎消膠囊治療,3次/d,3粒/次。兩組連續(xù)給藥1周。比較兩組的臨床療效、復發(fā)率、癥狀改善時間、氧化應激指標、炎癥反應指標。結(jié)果 治療后,治療組總有效率(95.00%)高于對照組(83.33%),復發(fā)率(6.67%)低于對照組(20.00%),差異均有統(tǒng)計學意義(P<0.05)。治療后,治療組陰道壁充血消失、白帶異常、小便后灼熱感、小腹脹痛和陰道口瘙癢改善時間短于對照組(P<0.05)。治療后,兩組血清超氧化物歧化酶(SOD)水平升高,血清一氧化氮(NO)、丙二醛(MDA)、超敏C反應蛋白(hs-CRP)、白細胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)水平下降(P<0.05),且治療組血清SOD水平高于對照組,血清NO、MDA、hs-CRP、IL-6和TNF-α水平低于對照組(P<0.05)。結(jié)論 婦炎消膠囊聯(lián)合甲硝唑片治療細菌性陰道病的療效顯著,有利于縮短臨床癥狀改善時間,改善氧化應激反應,降低炎癥因子指標,預防疾病復發(fā)。
[Key word]
[Abstract]
Objective To explore the clinical efficacy of Fuyanxiao Capsules combined with Metronidazole Tablets in treatment of bacterial vaginitis. Methods Patients (120 cases) with bacterial vaginitis in the 7th People's Hospital of Zhengzhou from January 2021 to January 2023 were divided into control and treatment groups according to the envelope randomization method, and each group had 60 cases. Patients in the control group were po administered with Metronidazole Tablets, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Fuyanxiao Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 1 week. The clinical efficacies, recurrence rates, the symptom improvement time, oxidative stress indicators, and inflammatory response indicators in two groups were compared. Results After treatment, the effective rate of the treatment group (95.00%) was higher than 83.33% of the control group, and the recurrence rate (6.67%) was lower than 20.00% of the control group, with statistical significance between two groups (P < 0.05). After treatment, the improvement time of vaginal wall congestion, abnormal vaginal discharge, burning sensation after urination, lower abdominal distension, and itching at the vaginal opening in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the serum levels of SOD in two groups increased but serum levels of NO, MDA, hs-CRP, IL-6, and TNF-α in two groups decreased (P < 0.05). The serum levels of SOD in the treatment group were higher than those in the control group, but serum levels of NO, MDA, hs-CRP, IL-6, and TNF-α in the treatment group were lower than those in the control group (P < 0.05). Conclusion Fuyanxiao Capsules combined with Metronidazole Tablets is effective in treatment of bacterial vaginitis, which is beneficial for shortening the time for clinical symptom improvement, improving oxidative stress response, reducing inflammatory factor indicators, and preventing disease recurrence.
[中圖分類號]
R984
[基金項目]
河南省醫(yī)學科技攻關(guān)計劃(聯(lián)合共建)項目(LHGJ20191322)