急性胰腺炎具有發(fā)病迅速、并發(fā)癥多、死亡率高等特點(diǎn)。川芎嗪可通過促進(jìn)細(xì)胞凋亡、糾正微循環(huán)障礙、減輕炎癥反應(yīng)、減輕脂質(zhì)過氧化反應(yīng)、抑制脂多糖/Toll樣受體4信號(hào)通路、保護(hù)小腸黏膜屏障功能發(fā)揮防治急性胰腺炎的作用。歸納了川芎嗪防治急性胰腺炎的作用機(jī)制，為急性胰腺炎的治療提供參考。

Acute pancreatitis is characterized by fatal, pathogenic and high mortality. Ligustrazine can play a role in prevention and treatment of acute pancreatitis by promoting cell apoptosis, correcting microcirculation disorders, alleviating inflammatory reactions, reducing lipid peroxidation, inhibiting LPS/TLR4 signaling pathways, and protecting the intestinal mucosal barrier function. This article summarizes the mechanism of ligustrazine in prevention and treatment of acute pancreatitis, providing reference for the treatment of acute pancreatitis.

R285;R975

重慶市大足區(qū)科技發(fā)展項(xiàng)目（DZKJ-2021ACC1014）