腦出血的發(fā)病急、進(jìn)展迅速、預(yù)后較差,成為威脅人類健康的重大疾病之一。水蛭素是從水蛭的唾液腺中分離出來的多肽,可通過抗凝血酶活性、抑制細(xì)胞凋亡、減輕氧化應(yīng)激反應(yīng)、降低炎癥反應(yīng)、抑制水通道蛋白4的表達(dá)、阻止膠質(zhì)纖維酸性蛋白的上調(diào)、抑制血小板反應(yīng)蛋白表達(dá)、調(diào)節(jié)Na⁺,K⁺-ATP酶的活性對腦出血發(fā)揮防治作用。綜述了水蛭素防治腦出血的藥理作用研究進(jìn)展,為水蛭素臨床治療腦出血提供依據(jù)。

Cerebral hemorrhage is one of the major diseases threatening human health because of its rapid onset, rapid progression, and poor prognosis. Hirudin is a peptide isolated from the salivary glands of Hirudo niponica Whitman. Hirudin can play a prevention and treatment role in cerebral hemorrhage by inhibiting thrombin activity, inhibiting cell apoptosis, reducing oxidative stress reaction, reducing inflammatory reaction, inhibiting the expression of aquaporin 4, inhibiting the upregulation of glial fibrillary acidic protein, inhibiting platelet reactive protein expression, and regulating the activity of Na⁺-K⁺ ATPase. This article reviews the pharmacological research progress of hirudin in prevention and treatment of cerebral hemorrhage, providing a basis for the clinical treatment of cerebral hemorrhage with hirudin.

R971

重慶市大足區(qū)科技計劃項目（DZKJ，2017ACC1029）