目的 探討芪參益氣滴丸聯(lián)合非洛地平緩釋片治療冠心病心絞痛的臨床療效。方法 選取2022年6月—2023年6月皖南醫(yī)學院第二附屬醫(yī)院收治的冠心病心絞痛患者90例，依據(jù)用藥情況分為對照組（45例）和治療組（45例）。對照組患者口服非洛地平緩釋片，5 mg/次，1次/d。在對照組的基礎(chǔ)上，治療組口服芪參益氣滴丸，1袋/次，3次/d。兩組治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀好轉(zhuǎn)時間，及磷酸肌酸酶同工酶（CK-MB）、磷酸肌酸激酶（CK）、乳酸脫氫酶（LDH）水平，6 min步行距離試驗量表（6MWT）、精神狀態(tài)評價量表（MMSE）和全球急性冠狀動脈事件注冊（GRACE）評分。結(jié)果 治療后，治療組總有效率為93.33%，明顯高于對照組（80.00%，P＜0.05）。治療后，治療組癥狀好轉(zhuǎn)時間均明顯早于對照組（P＜0.05）。治療后，兩組患者心肌酶中CK-MB、CK和LDH水平比治療前明顯降低（P＜0.05），且治療組明顯低于對照組（P＜0.05）。治療后，兩組患者6MWT和MMSE評分明顯升高，而GRACE評分明顯降低（P＜0.05），且治療組6MWT、MMSE評分和GRACE評分明顯好于對照組（P＜0.05）。結(jié)論 芪參益氣滴丸與非洛地平緩釋片協(xié)同治療，能較好的對心絞痛癥狀明顯改善，心肌供血能力增強，且有效改善運動耐受力、精神狀態(tài)，降低預后風險。

Objective To explore the clinical s efficacy of Qishen Yiqi Dropping Pills combined with felodipine in treatment of heart disease and angina pectoris. Methods Patients (90 cases) with heart disease and angina pectoris in the second affiliated Hospital of Wannan Medical College from June 2022 to June 2023 were divided into control (45 cases) and treatment (45 cases) group according to drug use. Patients in the control group were po administered with Felodipine Sustained Release Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Qishen Yiqi Dropping Pills on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, CK-MB, CK, LDH, 6MWD, MMSE and GRACE in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 93.33%, which was significantly higher than that of the control group (80.00%, P < 0.05). After treatment, the time of symptom improvement in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of CK-MB, CK, and LDH in myocardial enzymes in two groups were significantly lower than those before treatment (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the 6MWD test and MMSE score were significantly increased, while the GRACE score was significantly decreased in two groups (P < 0.05), and the 6MWD test, MMSE score and GRACE score in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic treatment of Qishen Yiqi Dropping Pills and felodipine can significantly improve the symptoms of angina pectoris, enhance myocardial blood supply, effectively improve exercise tolerance, mental state, and reduce the risk of prognosis.

R972

國家自然科學基金青年科學基金資助項目（81800445）