乳腺癌是女性常見的惡性腫瘤之一，其發(fā)病率和死亡率呈逐年上升趨勢(shì)。目前治療乳腺癌的大多數(shù)藥物會(huì)產(chǎn)生一些不良反應(yīng)。植物多糖具有多種生物活性，可通過抑制細(xì)胞增殖、抑制細(xì)胞遷移和侵襲、誘導(dǎo)細(xì)胞凋亡、調(diào)節(jié)細(xì)胞周期、抑制腫瘤血管生成、免疫調(diào)節(jié)、抗氧化等途徑抗乳腺癌。綜述了植物多糖抗乳腺癌的作用機(jī)制研究進(jìn)展，為植物多糖開發(fā)抗乳腺癌新藥提供參考。

Breast cancer is one of the most common malignant tumors in women, and its incidence rate and mortality are increasing year by year. At present, most of drugs for breast cancer will produce some adverse reactions. Plant polysaccharides have a variety of biological activities. They have anti-breast cancer effect by inhibiting cell proliferation, inhibiting cell migration and invasion, inducing apoptosis, regulating cell cycle, inhibiting tumor angiogenesis, immune regulation, antioxidant and other ways. This article reviews the research progress on the mechanism of plant polysaccharides against breast cancer, providing reference for the development of plant polysaccharides as new drugs against breast cancer.

R285

國家自然科學(xué)基金地區(qū)項(xiàng)目（31860252）;云南省自然科學(xué)基金地方高校聯(lián)合面上項(xiàng)目（202301BA070001-043）;云南省昆蟲生物醫(yī)藥研發(fā)重點(diǎn)實(shí)驗(yàn)室開放項(xiàng)目（AG2022006）