目的 探討西黃丸聯(lián)合地塞米松片治療漿細(xì)胞性乳腺炎的臨床療效。方法 選取2021年10月—2023年9月在邢臺(tái)市中心醫(yī)院接受治療的114例漿細(xì)胞性乳腺炎患者，按隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療，每組57例。對(duì)照組口服地塞米松片，4片/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服西黃丸，3 g/次，2次/d。兩組患者的治療時(shí)間1個(gè)月。比較兩組的臨床療效、癥狀消失時(shí)間、疼痛程度、超聲指標(biāo)和血清指標(biāo)。結(jié)果 治療后，治療組的總有效率為92.98%，高于對(duì)照組的總有效率78.95%，差異具有有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，治療組疼痛、紅腫、腫塊、乳頭溢液消失時(shí)間均短于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。治療后，兩組視覺模擬評(píng)分法（VAS）評(píng)分均顯著降低（P＜0.05），且治療組的VAS評(píng)分低于對(duì)照組（P＜0.05）。治療后，兩組的SR、乳腺腫塊最大直徑比治療前?。?i>P＜0.05）；治療組的應(yīng)變率（SR）、乳腺腫塊最大直徑比對(duì)照組?。?i>P＜0.05）。治療后，兩組的血清細(xì)胞間黏附分子1（ICAM-1）、Toll樣受體2（TLR2）、白細(xì)胞介素-37（IL-37）水平比治療前低（P＜0.05）；治療組的血清ICAM-1、TLR2、IL-37水平比對(duì)照組小（P＜0.05）。結(jié)論 西黃丸聯(lián)合地塞米松片可提高漿細(xì)胞性乳腺炎的療效，改善臨床癥狀，減輕患者疼痛程度，降低炎癥反應(yīng)和腫塊大小。

Objective To investigate the clinical effect of Xihuang Pills combined with Dexamethasone Acetate Tablets in treatment of plasma cell mastitis. Methods Patients (114 cases) with plasma cell mastitis in Xingtai Central Hospital from October 2021 to September 2023 were divided into control and treatment groups according to the random number table method, and each group had 57 cases. Patients in the control group were po administered with Dexamethasone Acetate Tablets, 4 tablets/time, twice daily. Patients in the treatment group were po administered with Xihuang Pills on the basis of the control group, 3 g/time, twice daily. Patients in two groups were treated for 1 month. The clinical efficacies, the symptom disappearance time, degree of pain, ultrasound indicators, and serum indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group was 92.98%, which was higher than 78.95% of the control group, and the difference was statistically significant (P < 0.05). After treatment, the disappearance time of pain, redness, mass, and nipple discharge in the treatment group was shorter than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, VAS score of two groups was significantly decreased (P < 0.05), and VAS score of the treatment group was lower than that of the control group (P < 0.05). After treatment, SR and maximum diameter of breast mass were smaller than before treatment (P < 0.05), and SR and maximum diameter of breast mass in the treatment group were smaller than those in the control group (P < 0.05). After treatment, the serum levels of ICAM-1, TLR2, and IL-37 in two groups were lower than those before treatment (P < 0.05), and the serum levels of ICAM-1, TLR2, and IL-37 in the treatment group were lower than those in the control group (P< 0.05). Conclusion Xihuang Pills combined with Dexamethasone Acetate Tablets can improve the efficacy of plasma cell mastitis, further improve the clinical symptoms, reduce the pain degree of patients, and reduce the inflammatory response and tumor size.

R984

邢臺(tái)市重點(diǎn)研發(fā)計(jì)劃自籌項(xiàng)目（2023ZC065）