[關(guān)鍵詞]
[摘要]
目的 探討濟(jì)生腎氣丸聯(lián)合厄貝沙坦治療糖尿病腎病的臨床療效。方法 選擇2021年1月—2023年5月成都市新都區(qū)中醫(yī)醫(yī)院收治的糖尿病腎病患者100例,依據(jù)隨機(jī)數(shù)表法分為對照組(50例)和治療組(50例)。對照組患者口服厄貝沙坦片,150 mg/d,1次/d。治療組患者在對照組基礎(chǔ)上口服濟(jì)生腎氣丸,6 g/次,3次/d。兩組患者治療3個月。觀察兩組患者臨床療效,比較治療前后兩組患者中醫(yī)癥狀改善時間,尿素氮、視黃醇結(jié)合蛋白(RBP)、肌酐、白細(xì)胞介素-6(IL-6)、C反應(yīng)蛋白(CRP)和白細(xì)胞介素-10(IL-10)水平。結(jié)果 治療后,治療組患者總有效率為94.00%,比對照組的80.00%明顯升高(P<0.05)。治療后,治療組肢體水腫、小便渾濁、腰膝酸軟的改善時間明顯短于對照組(P<0.05)。治療后,兩組尿素氮、RBP、肌酐、IL-6和CRP水平均明顯降低,而IL-10水平明顯升高(P<0.05),且與對照組比較,治療組尿素氮、RBP、肌酐、IL-6、CRP和IL-10水平明顯好于對照組(P<0.05)。結(jié)論 濟(jì)生腎氣丸聯(lián)合厄貝沙坦治療糖尿病腎病可獲得較為理想的治療效果,能改善患者的中醫(yī)癥狀和腎功能,減輕體內(nèi)炎癥反應(yīng)。
[Key word]
[Abstract]
Objective To explore the therapeutic effect of Jisheng Shenqi Pills combined with irbesartan in treatment of diabetes nephropathy. Methods Patients (100 cases) with diabetes nephropathy in Xindu Hospital of Traditional Chinese Medicine from January 2021 to May 2023 were divided into control (50 cases) and treatment (50 cases) group according to random number table method. Patients in the control group were po administered with Irbesartan Tablets, 150 mg/d, once daily. Patients in the treatment group were po administered with Jisheng Shenqi Pills on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical evaluations were evaluated, the improvement time of TCM symptoms, the levels of urea nitrogen, RBP, creatinine, IL-6, CRP, and IL-10 in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 94.00%, which was significantly higher than that of the control group (80.00%, P < 0.05). After treatment, the improvement time of TCM symptoms such as limb edema, turbid urine, sore waist, and knees in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of blood urea nitrogen, RBP, creatinine, IL-6, and CRP were significantly decreased, while the level of IL-10 was significantly increased in two groups (P < 0.05). Compared with the control group, the levels of blood urea nitrogen, RBP, creatinine, IL-6, CRP, and IL-10 in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Jisheng Shenqi Pills combined with irbesartan in treatment of diabetes nephropathy can obtain ideal therapeutic effect, improve the TCM symptoms and renal function of patients, and reduce the inflammatory reaction in vivo.
[中圖分類號]
R983
[基金項目]
四川省中醫(yī)藥管理局科學(xué)技術(shù)研究專項課題(2021MS316)