目的 對亳州市人民醫(yī)院納洛酮使用進行合理性評價，促進臨床合理使用納洛酮。方法 以納洛酮說明書為基礎，結合相關指南、專家共識及文獻，建立納洛酮藥物利用評價（DUE）細則，并以此為依據(jù)，運用屬性層次模式的方法對亳州市人民醫(yī)院2023年1月1日—2023年12月1日納洛酮的使用情況進行合理性評價。結果 在評價的151份病歷中，優(yōu)秀病歷占比2.65%，良好病歷28.48%，合格64.90%，不合格3.97%，不合理應用主要表現(xiàn)在適應證不合理、用量不合理、療程不合理和無用藥監(jiān)測。結論 評價結果反映納洛酮在臨床使用中存在的不合理現(xiàn)象，需進一步加強管控。

Objective To evaluate the rationality of naloxone use in Bozhou People’s Hospital, and promote the rational use of naloxone in clinical practice. Methods The naloxone drug utilization evaluation (DUE) rules were established based on the naloxone instruction manual, combined with related guidelines, expert consensus and literature. Based on this, the use of naloxone in Bozhou People’s Hospital from January 1, 2023 to December 1, 2023 was rationally evaluated by using attribute hierarchy model. Results Among the 151 medical records evaluated, excellent medical records accounted for 2.65%, good medical records 28.48%, qualified 64.90%, and unqualified 3.97%. Irrational use was mainly manifested in unreasonable indications, unreasonable dosage, unreasonable course of treatment, and no drug monitoring. Conclusion The evaluation results reflect the unreasonable phenomenon in the clinical use of naloxone, which needs to be further strengthened.

R971

安徽省高等學?？茖W研究項目（自然科學類）（2023AH053213）