胰腺癌是一種消化道常見(jiàn)惡性腫瘤之一，預(yù)后差，診斷期較晚。雷公藤甲素是雷公藤中有效成分之一，具有顯著的藥理活性。雷公藤甲素可通過(guò)抑制細(xì)胞周期和增殖、誘導(dǎo)細(xì)胞凋亡、抑制細(xì)胞遷移和侵襲、調(diào)節(jié)腫瘤血管生成、協(xié)同其他藥物抗耐藥、抑制熱休克蛋白相關(guān)基因、誘導(dǎo)自噬等多種途徑治療胰腺癌?？偨Y(jié)了雷公藤甲素治療胰腺癌的藥理作用及其作用機(jī)制的研究進(jìn)展，為雷公藤甲素成為胰腺癌治療的候選藥物提供依據(jù)。

Pancreatic cancer is one of the common malignant tumors of digestive tract, with poor prognosis and late diagnosis. Triptolide is one of the effective ingredients in Tripterygii Radix et Rhizoma, with significant pharmacological activity. Triptolide can treat pancreatic cancer by inhibiting cell cycle and proliferation, inducing apoptosis, inhibiting cell migration and invasion, regulating tumor angiogenesis, cooperating with other drugs to resist drug resistance, inhibiting heat shock protein related genes, inducing autophagy. This article summarized the pharmacological action and mechanism of triptolide in treatment of pancreatic cancer, providing a basis for triptolide to become a candidate drug for the treatment of pancreatic cancer.

R965

河南省自然科學(xué)基金優(yōu)秀青年基金項(xiàng)目（212300410057）；河南省科技研發(fā)計(jì)劃聯(lián)合基金項(xiàng)目（222301420060）