肺部感染臨床常以肺炎形式存出現(xiàn)，治療核心為抗感染，但多數(shù)病原菌對傳統(tǒng)藥物具有較高的耐藥性。小檗堿是從黃連中提取的活性成分，具有多種活性，可通過降低病原菌耐藥性，阻止病原菌復(fù)制，減輕肺部炎癥反應(yīng)，調(diào)節(jié)免疫功能，抑制肺纖維化進(jìn)程，保護(hù)血管內(nèi)皮細(xì)胞以治療肺部感染，減輕肺組織損傷。綜述了小檗堿用于肺部感染治療的藥理作用研究進(jìn)展，為小檗堿臨床治療肺部感染提供依據(jù)。

Pulmonary infections often occur in the form of pneumonia in clinical practice, and the core treatment is anti-infection. However, most pathogens have high resistance to traditional drugs. Berberine is an active ingredient extracted from Coptidis Rhizoma, which has various activities. Berberine can reduce pathogen resistance, prevent pathogen replication, alleviate pulmonary inflammatory response, regulate immune function, inhibit pulmonary fibrosis process, and protect vascular endothelial cells, so as to treat lung infection and reduce lung tissue damage. This article reviews the pharmacological research progress of berberine in treatment of pulmonary infections, providing a basis for the clinical treatment of pulmonary infections with berberine.

R965;R974

重慶市科衛(wèi)聯(lián)合醫(yī)學(xué)科研項目（2019ZDXM042）