腎臟疾病可造成腎組織不同程度的損傷，導(dǎo)致腎功能下降。丹參酮Ⅱ_A是從丹參中分離得到的脂溶性二萜醌，具有多種藥理作用，可通過減輕炎癥反應(yīng)，減輕氧化應(yīng)激反應(yīng)，延緩腎組織纖維化，抑制細胞凋亡，增強細胞自噬，改善血液流變學(xué)，促進有害物質(zhì)外流對腎功能發(fā)揮保護作用?？偨Y(jié)了丹參酮Ⅱ_A治療腎損傷的藥理作用研究進展，為丹參酮Ⅱ_A在腎臟疾病中臨床應(yīng)用提供參考。

Kidney disease can cause varying degrees of damage to renal tissue, leading to a decrease in renal function. Tanshinone II_A is a lipid soluble diterpenoid quinone isolated from Salviae Miltiorrhizae Radix etRhizoma, which has various pharmacological effects. Tanshinone II_A can alleviate inflammation response, reduce oxidative stress reaction, delay renal tissue fibrosis, reduce cell apoptosis, enhance cell autophagy, improve hemorheology, and promote the efflux of harmful substances, thus it play a protective role in renal function. This article summarizes the pharmacological research progress of tanshinone II_A in treatment of kidney injury, providing reference for the clinical application of tanshinone II_A in kidney diseases.

R965

衛(wèi)生健康發(fā)展促進項目（KM-MXQD-002）