[關鍵詞]
[摘要]
目的 探討健脾生血片聯(lián)合復方硫酸亞鐵顆粒治療妊娠期缺鐵性貧血的臨床療效。方法 選取2021年10月—2023年10月在延安大學咸陽醫(yī)院治療的妊娠期缺鐵性貧血患者106例,按照隨機數(shù)表法分為對照組(53例)和治療組(53例)。對照組飯后口服復方硫酸亞鐵顆粒,1袋/次,1次/d。治療組在對照組基礎上飯后口服健脾生血片,3片/次,3次/d。兩組患者連續(xù)治療4周。觀察兩組患者臨床療效,比較治療前后兩組患者中醫(yī)癥狀改善時間及血紅蛋白(Hb)、紅細胞計數(shù)、紅細胞比容、鐵調素、鐵蛋白和總鐵結合力水平。結果 治療后,治療組總有效率為94.34%,與對照組的81.13%比較明顯升高(P<0.05)。與對照組比較,治療后治療組體倦乏力、食欲不振、面色萎黃改善時間明顯縮短(P<0.05)。與治療前比較,兩組Hb、紅細胞計數(shù)、紅細胞比容、鐵調素、鐵蛋白水平均明顯升高,而總鐵結合力水平明顯降低(P<0.05),且與對照組治療后比較,治療組患者改善更明顯(P<0.05)。結論 健脾生血片聯(lián)合復方硫酸亞鐵顆粒治療妊娠期缺鐵性貧血可獲得較好的臨床效果,能有效改善患者的中醫(yī)癥狀、紅細胞相關指標以及鐵代謝。
[Key word]
[Abstract]
Objective To explore the therapeutic effect of Jianpi Shengxue Tablets combined with compound ferrous sulfate in treatment of iron deficiency anemia during pregnancy. Methods Patients (106 cases) with iron deficiency anemia during pregnancy in Yan'an University Xianyang Hospital from October 2021 to October 2023 were divided into control group (53 cases) and treatment group (53 cases) according to random number table method. Patients in the control group were po administered with Compound Ferrous Sulfate Granules after meals, 1 bag/time, once daily. Patients in the treatment group were po administered with Jianpi Shengxue Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, the improvement time for TCM symptoms, the levels of Hb, red blood cell count, hematocrit, hepcidin, ferritin and total iron binding capacity in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 94.34%, which was significantly higher than that of the control group (81.13%, P < 0.05). Compared with the control group, the improvement time of fatigue, loss of appetite and sallow complexion in the treatment group was significantly shorter than that in the control group (P < 0.05). Compared with before treatment, the levels of Hb, red blood cell count, hematocrit, ferritin were significantly increased, while the total iron binding capacity were significantly decreased in two groups (P < 0.05), and compared with the control group, the improvement in the treatment group of there indexes was more obvious (P < 0.05). Conclusion Jianpi Shengxue Tablets combined with compound ferrous sulfate in treatment of iron deficiency anemia during pregnancy can obtain better clinical effect, and effectively improve the TCM symptoms, erythrocyte related indexes and iron metabolism of patients.
[中圖分類號]
R984
[基金項目]
陜西省科技計劃項目(2019SF-050)