目的 建立西維來司他鈉的藥物利用評價（DUE）標準，應用加權TOPSIS法評價其臨床應用的合理性，為臨床合理使用西維來司他鈉提供參考。方法 以西維來司他鈉藥品說明書、相關共識等為參考，制定西維來司他鈉合理用藥評價標準。根據制定的標準，利用PASS系統(tǒng)抽取2023年1月—12月六安市人民醫(yī)院使用西維來司他鈉的128份住院患者的病例信息，并采用加權TOPSIS法對抽取的病歷進行分析，評價用藥合理性。結果 西維來司他鈉完全符合評價標準的病例有63例（49.2%），用藥不適宜主要表現在適應證43例（33.6%）、輔助檢查及實驗室檢查27例（21.1%）、用法用量18例（14.1%）、用藥療程18例（14.1%）、不良反應10例（12.8%）。通過加權TOPSIS法，判定為合理用藥83例（64.8%），基本合理用藥5例（3.9%），不合理用藥40例（31.3%）。結論 通過建立西維來司他鈉臨床應用的合理性評價標準，發(fā)現西維來司他鈉臨床使用合理率占比較高，但仍存在使用不合理現象，通過前置審方系統(tǒng)完善西維來司他鈉用藥規(guī)則，促進藥物合理、規(guī)范使用。

Objective To establish the criteria for drug utilization evaluation (DUE) of sivelestat sodium, and apply the weighted TOPSIS method to evaluate the rationality of its clinical application, so as to provide reference for rational clinical use of sivelestat sodium. Methods The evaluation criteria for rational drug use of sivelestat sodium were established with reference to the drug instructions and relevant consensus of sivelestat sodium. According to the established criteria, the data of 128 inpatients using cilvelestat sodium in Lu’an People’s Hospital from January to December 2023 were extracted by the PASS system, and the extracted medical records were analyzed by weighted TOPSIS method to evaluate the rationality of drug use. Results There were 63 cases (49.2%) in which sivelestat sodium fully met the evaluation criteria. The inappropriateness of medication was mainly manifested in: There were 43 cases (33.6%) of indications, 27 cases (21.1%) of auxiliary examination and laboratory examination, 18 cases (14.1%) of usage and dosage, 18 cases (14.1%) of treatment course, and 10 cases (12.8%) of adverse reactions. By weighted TOPSIS method, 83 cases (64.8%) were judged to be rational drug use, 5 cases (3.9%) were basically rational drug use, and 40 cases (31.3%) were irrational drug use. Conclusion Through the establishment of rational evaluation criteria for clinical application of sivelestat sodium, it can be seen from the results that the rational rate of clinical use of sivelestat sodium is relatively high, but there are still irrational use. The pre-review prescription system is used to improve the medication rules of sivelestat sodium, and promote the rational and standardized use of drugs.

R974

安徽省教育廳高?？茖W研究項目（KJ2021A0342）