抗癌肽是含有5～50個(gè)氨基酸的小型陽(yáng)離子肽?？拱╇木哂歇?dú)特的抗癌機(jī)制，如破壞細(xì)胞膜、誘導(dǎo)細(xì)胞凋亡、抑制血管生成、免疫調(diào)節(jié)、誘導(dǎo)DNA損傷和抑制細(xì)胞增殖?？拱╇脑谥委煱┌Y方面具有巨大的潛力，但在臨床上應(yīng)用尚未成熟，仍處于臨床試驗(yàn)階段?？偨Y(jié)了抗癌肽的抗腫瘤作用機(jī)制、臨床應(yīng)用情況，以期為抗癌肽開發(fā)為新型高效低毒的抗癌藥物提供思路。

Anticancer peptides are small cationic peptides containing 5 to 50 amino acids. Anticancer peptides have unique anticancer mechanisms, such as destroying cell membranes, inducing apoptosis, inhibiting angiogenesis, immune regulation, inducing DNA damage, and inhibiting cell proliferation. Anticancer peptides have great potential in treatment of cancer, but their clinical application is not yet mature and is still in the clinical trial stage. This article summarizes the anti-tumor mechanism and clinical application of anticancer peptides, in order to provide ideas for the development of anticancer peptides as new highly efficient and low toxicity anticancer drugs.

R966

廣東省促進(jìn)經(jīng)濟(jì)高質(zhì)量發(fā)展（海洋經(jīng)濟(jì)發(fā)展）海洋六大產(chǎn)業(yè)專項(xiàng)基金（GDNRC[2022]38）