目的 采用多指標(biāo)成分測(cè)定結(jié)合化學(xué)計(jì)量學(xué)評(píng)價(jià)金花消痤丸的質(zhì)量。方法 采用HPLC法測(cè)定10批金花消痤丸中梔子苷、鹽酸小檗堿、黃芩苷、漢黃芩苷、黃芩素、漢黃芩素、蘆薈大黃素、大黃素、大黃酚、大黃素甲醚，結(jié)合聚類(lèi)分析、主成分分析、正交偏最小二乘法-判別分析評(píng)價(jià)不同批次金花消痤丸樣品的質(zhì)量差異。結(jié)果 10批金花消痤丸樣品分為兩類(lèi)，樣品間差異不大，較類(lèi)似。4個(gè)主成分的累計(jì)方差貢獻(xiàn)率達(dá)到了83.201%。結(jié)論 方法簡(jiǎn)單快捷，重復(fù)性好，精密度優(yōu)良，結(jié)果較準(zhǔn)確，可以為金花消痤丸的質(zhì)量控制提供參考。

Objective To evaluate the quality of Jinhua Xiaocuo Pills by multi-index component analysis combined with chemometrics. Methods HPLC method was used to determine contents of geniposide, berberine hydrochloride, baicalin, wogonoside, baicalein, wogonin, aloe emodin, emodin, chrysophanol, and emodin-3-methyl ether in 10 batches of Jinhua Xiaocuo Pills. Cluster analysis, principal component analysis, and orthogonal partial least squares discriminant analysis were used to evaluate the quality differences of different batches of Jinhua Xiaocuo Pills. Results The 10 batches of Jinhua Xiaocuo Pills were divided into two categories, with little difference between the samples, and were relatively similar. The total cumulative contribution value of the four principal components reached 83.201%. Conclusion This method is simple, fast, has good repeatability, excellent precision, and accurate results, which can provide reference for the quality control of Jinhua Xiaocuo Pills.

R286.02

安徽省教育廳高校優(yōu)秀人才支持計(jì)劃(gxyq2021277)