目的 探討腰痹通膠囊聯(lián)合地奧司明片治療腰椎管狹窄癥的臨床療效。方法 選取2021年6月—2024年5月在張家口市第一醫(yī)院就診的94例腰椎管狹窄癥患者，按隨機數(shù)字表法將患者分為對照組和治療組，每組47例。對照組午餐、晚餐后口服地奧司明片，1片/次。治療組在對照組基礎(chǔ)上口服腰痹通膠囊，3粒/次，3次/d。兩組患者持續(xù)治療4周。比較兩組患者的臨床療效、腰椎功能和血清指標(biāo)。結(jié)果 治療后，治療組的總有效率為95.74%，對照組的總有效率為82.98%，組間比較差異顯著（P＜0.05）。治療后，兩組Oswestry功能障礙指數(shù)（ODI）評分顯著減?。?i>P＜0.05），且治療組ODI評分較對照組更?。?i>P＜0.05）。治療后，兩組的血清白細(xì)胞介素-1α（IL-1α）、基質(zhì)金屬蛋白酶-3（MMP-3）、白細(xì)胞介素-18（IL-18）水平均降低（P＜0.05）；治療組的血清IL-1α、MMP-3、IL-18水平均低于對照組（P＜0.05）。結(jié)論 腰痹通膠囊聯(lián)合地奧司明片可提高腰椎管狹窄癥的療效，改善患者腰椎功能，降低炎癥反應(yīng)。

Objective To investigate the clinical study of Yaobitong Capsules combined with Diosming Tablets in treatment of lumbar spinal stenosis. Methods 94 Patients with lumbar spinal stenosis who visited Zhangjiakou First Hospital from June 2021 to May 2024 were selected and divided into control group and treatment group using a random number table method, with 47 patients in each group. The patients in the control group were po administered with Diosmin Tablets after lunch and dinner, 1 tablets/time. The patients in the treatment group were po administered with Yaobitong Capsules on the basis of the control group, 3 grains/time, 3 times daily. Two groups of patients were treated continuously for 4 weeks. The clinical efficacy, lumbar function, and serum indexes of the two groups were compared. Results After treatment, the total effective rate was 95.74% in the treatment group, and 82.98% in the control group, and the difference was significant between two groups (P < 0.05). After treatment, ODI scores of the two groups was significantly decreased (P < 0.05), and ODI score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the serum levels of IL-1α, MMP-3, and IL-18 in two groups were decreased (P < 0.05), and the serum levels of IL-1α, MMP-3, and IL-18 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Yaobitong Capsules combined withDiosming Tablets can improve the curative effect of lumbar spinal stenosis, improve the function of lumbar spine and reduce the inflammatory response.

R971

張家口市重點研發(fā)計劃項目(2121059D)