目的 探討小兒荊杏止咳顆粒聯(lián)合利巴韋林治療小兒急性上呼吸道感染的臨床療效。方法 選取2022年5月—2024年5月承德市中心醫(yī)院收治的急性上呼吸道感染患兒84例，依據(jù)用藥情況將患兒分為對照組（42例）和治療組（42例）。對照組患兒口服利巴韋林顆粒，50 mg/次，2次/d。在對照組的基礎(chǔ)上，治療組口服小兒荊杏止咳顆粒，3～5歲半袋/次；6歲以上1袋/次，3次/d。兩組用藥7 d觀察治療情況。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀消失時間，睡眠質(zhì)量，及血清淀粉樣蛋白（SAA）、血清腺普脫氨酶（ADA）、前白蛋白（PA）和γ干擾素（IFN-γ）水平。結(jié)果 治療后，治療組總有效率為95.24%，明顯高于對照組的78.57%（P＜0.05）。治療后，與對照組比較，治療組發(fā)熱、頭痛、咽痛、鼻塞等癥狀消失時間均明顯縮短（P＜0.05）。治療后，兩組患兒睡眠質(zhì)量評分明顯降低（P＜0.05），且治療組兒童睡眠習(xí)慣問卷表（CSHQ）評分降低更明顯（P＜0.05）。治療后，兩組SAA和ADA水平明顯降低，而PA和IFN-γ水平明顯升高（P＜0.05），且治療組SAA、ADA、PA和IFN-γ水平明顯好于對照組（P＜0.05）。結(jié)論 小兒荊杏止咳顆粒聯(lián)合利巴韋林治療小兒急性上呼吸道感染，能明顯改善患兒的呼吸道感染癥狀及體征，減弱局部炎癥反應(yīng)，增強機體免疫能力，有效提升睡眠質(zhì)量。

Objective To explore the clinical effect of Xiao’er Jingxing Zhike Granules combined with ribavirin in treatment of acute upper respiratory tract infection in children. Methods Children (84 cases) with acute upper respiratory tract infection in Chengde Central Hospital from May 2022 to May 2024 were divided into control (42 cases) and treatment (42 cases) group based on different treatments. Children in the control group were po administered with Ribavirin Granules, 50 mg/time, twice daily. Children in the treatment group were po administered with Xiao'er Jingxing Zhike Granules on the basis of the control group, 0.5 bag/time for 3—5 years old children, 1 bag/time for more than 6 years old children, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom disappearance time, CSHQ scores, the serological levels of SAA, ADA, PA and IFN-γ in two groups before and after treatment were compared. Results After treatment, the effective rate in the treatment group was 95.24%, which was significantly higher than that in the control group (78.57%, P < 0.05). After treatment, compared with the control group, the disappearance time for symptoms such as fever, headache, sore throat, and nasal congestion in the treatment group was significantly shortened (P < 0.05). After treatment, the sleep quality scores in two groups were significantly decreased (P < 0.05), and the CSHQ scores were decreased more significantly in the treatment group (P < 0.05). After treatment, the levels of SAA and ADA were significantly decreased intwo groups, while the levels of PA and IFN-γ were significantly increased (P < 0.05). The levels of SAA, ADA, PA and IFN-γ in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The coordinated treatment of ribavirin and Xiao’er Jingxing Zhike Granules can significantly improve the symptoms and signs of respiratory infection in children, weaken local inflammatory reactions, enhance the body's immunity, and effectively improve the sleep quality of children.

R974

河北省醫(yī)學(xué)科學(xué)研究重點課題項目(20191299);承德市科學(xué)技術(shù)與發(fā)展研究課題計劃項目(202204A018)