目的 觀察尪痹片聯(lián)合洛索洛芬鈉片治療類風(fēng)濕關(guān)節(jié)炎的治療效果。方法 選取無錫市中醫(yī)醫(yī)院2021年1月—2023年1月101例類風(fēng)濕性關(guān)節(jié)炎患者，采用隨機(jī)數(shù)字表＋密封信法將所有患者分成對照組（51例）和治療組（50例）。對照組口服洛索洛芬鈉片，1片/次，3次/d。治療組在此基礎(chǔ)上口服尪痹片，4片/次，3次/d。兩組連續(xù)治療3個月。比較兩組臨床療效、關(guān)節(jié)壓痛、腫脹個數(shù)、免疫指標(biāo)、血清因子和血清炎癥因子。結(jié)果 經(jīng)過治療，治療組患者的總有效率（96.00%）較對照組（82.35%）更高（P＜0.05）。經(jīng)過治療，兩組關(guān)節(jié)壓痛、腫脹個數(shù)均減少 P＜0.05）；治療組關(guān)節(jié)壓痛、腫脹個數(shù)少于對照組（P＜0.05）。經(jīng)過治療，兩組外周血輔助性T細(xì)胞17（Th17）、Th17/Treg比值、紅細(xì)胞沉降率（ESR）、血清C-反應(yīng)蛋白（CRP）、類風(fēng)濕因子（RF）、抗環(huán)瓜氨酸多肽抗體（anti-CCP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平均降低，調(diào)節(jié)性T細(xì)胞（Treg）均升高（P＜0.05）；治療組外周血Th17、Th17/Treg、ESR、血清CRP、RF、anti-CCP、IL-6、TNF-α水平低于對照組，Treg高于對照組（P＜0.05）。結(jié)論 尪痹片聯(lián)合洛索洛芬鈉片治療類風(fēng)濕關(guān)節(jié)炎的效果良好，可有效減少關(guān)節(jié)壓痛和腫脹，改善免疫功能和炎癥反應(yīng)。

Objective To observe the therapeutic effect of Wangbi Capsules combined with Loxoprofen Sodium Tablets in treatment of rheumatoid arthritis. Methods A total of 101 patients with rheumatoid arthritis in Wuxi Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected, and were divided into a control group (51 cases) and a treatment group (50 cases) using a random number table and sealed letter method. Patients of the control group orally took Loxoprofen Sodium Tablets, 1 tablets/time, 3 times daily. On this basis, patients in the treatment group orally took Wangbi Capsules, 4 tablets/time, 3 times daily. Patients of two groups were treated for 3 months. The clinical efficacy, joint tenderness, number of swelling, immune indicators, serum factors, and serum inflammatory factors were compared between two groups. Results After treatment, the total effective rate (96.00%) of the treatment group was higher than 82.35% of the control group (P < 0.05). After treatment, the number of joint tenderness and swelling in both groups decreased (P < 0.05), and the number of joint tenderness and swelling in the treatment group was less than that in the control group (P < 0.05). After treatment, peripheral blood T helper cell 17 (Th17), Th17/Treg ratio, ESR, levels of serum CRP, RF, anti-CCP, IL-6, and TNF-α in both groups were decreased, while regulatory T cells (Treg) were increased (P< 0.05). The peripheral blood Th17), Th17/Treg ratio, ESR, levels of serum CRP, RF, anti-CCP, IL-6, and TNF-α in the treatment group were lower than those in the control group, while Treg levels were higher than those in the control group (P < 0.05). Conclusion The combination of Wangbi Capsules and Loxoprofen Sodium Tablets has shown good efficacy in treating rheumatoid arthritis, effectively reducing joint tenderness and swelling, and improving immune function and inflammatory response.

R982

無錫市衛(wèi)生健康委科研項(xiàng)目(Q201916)