皮膚病可引起不同程度的瘙癢、疼痛，影響美觀，還嚴(yán)重影響患者的生活質(zhì)量。苦參堿是苦參中提取的生物堿，具有多種藥理作用，可通過(guò)調(diào)節(jié)免疫反應(yīng)、減輕炎癥損傷、增強(qiáng)細(xì)胞自噬、促進(jìn)細(xì)胞凋亡、鎮(zhèn)痛止癢、抗皮膚纖維化等多途徑、多靶點(diǎn)對(duì)多種皮膚病發(fā)揮治療作用?？偨Y(jié)了苦參堿治療皮膚疾病的藥理作用研究進(jìn)展，為苦參堿的臨床應(yīng)用提供參考。

Skin diseases can cause varying degrees of itching, pain, affect aesthetics, and seriously affect the quality of life of patients. Matrine is an alkaloid from Sophorae Flavescentis Radix, which has various pharmacological effects. Matrine can treat various skin diseases through multiple pathways and targets, such as regulating immune response, reducing inflammatory damage, enhancing cell autophagy, promoting cell apoptosis, relieving pain and itching, and resisting skin fibrosis. This article summarizes the pharmacological research progress of matrine in treatment of skin diseases, providing reference for the clinical application of matrine.

R986

國(guó)家自然科學(xué)基金資助項(xiàng)目(81973846)