急性肺損傷是一種急性炎癥性肺部疾病，嚴(yán)重者可發(fā)生急性呼吸衰竭。臨床治療急性肺損傷主要控制炎癥反應(yīng)和改善臨床癥狀。木犀草素是一種天然的黃酮類化合物，具有多種生物學(xué)作用，可通過降低炎癥反應(yīng)、降低氧化應(yīng)激反應(yīng)、抑制細(xì)胞凋亡、改善肺上皮離子轉(zhuǎn)運(yùn)功能發(fā)揮防治急性肺損傷的作用?？偨Y(jié)了木犀草素防治急性肺損傷的藥理作用研究進(jìn)展，為木犀草素的臨床應(yīng)用提供參考。

Acute lung injury is an acute inflammatory lung disease, and severe cases can lead to acute respiratory failure. The clinical treatment of acute lung injury mainly controls inflammatory response and improves clinical symptoms. Luteolin is a natural flavonoid compound with multiple biological functions. Luteolin can prevent and treat acute lung injury by reducing inflammation, oxidative stress, cell apoptosis, and improving the ion transport function of lung epithelium. This article summarizes the pharmacological research progress of luteolin in prevention and treatment of acute lung injury, providing reference for the clinical application of luteolin.

R974

中央高水平中醫(yī)醫(yī)院臨床研究和成果轉(zhuǎn)化能力提升項(xiàng)目(HLCMHPP20230;HLCMHPP2023092)