高尿酸血癥是造成痛風(fēng)關(guān)節(jié)炎的獨(dú)立危險(xiǎn)因素。臨床治療高尿酸血癥主要是降酸劑，但長(zhǎng)期使用具有一些嚴(yán)重的不良反應(yīng)。槲皮素屬于黃酮醇類化合物，具有多種藥理作用，可通過降低尿酸產(chǎn)生、促進(jìn)尿酸鹽排泄、減輕炎癥反應(yīng)、降低氧化應(yīng)激反應(yīng)、調(diào)控腸道菌群、降低腎臟損傷發(fā)揮防治高尿酸血癥的作用?？偨Y(jié)了槲皮素防治高尿酸血癥的藥理作用研究進(jìn)展，為槲皮素的臨床應(yīng)用提供依據(jù)。

Hyperuricemia is an independent risk factor for gouty arthritis. The main clinical treatment for hyperuricemia is acid lowering agents, but long-term use has some serious adverse reactions. Quercetin belongs to flavonol compounds and has various pharmacological effects. Quercetin can prevent and treat hyperuricemia by reducing uric acid production, promoting urate excretion, alleviating inflammatory reactions, reducing oxidative stress reactions, regulating gut microbiota, and reducing kidney damage. This article summarizes the research progress on pharmacological effects of quercetin in preventing and treating hyperuricemia, providing support for the clinical application of quercetin.

R977

重慶市大足區(qū)科技發(fā)展項(xiàng)目(DZKJ2022JSYJ-KWXM1030)