再生障礙性貧血是一種以全血細(xì)胞減少、骨髓衰竭為特征的血液免疫功能障礙，其中免疫抑制療法是最常用的治療方案。穿龍薯蕷皂苷的結(jié)構(gòu)類(lèi)似于類(lèi)固醇激素，具有多種藥理作用，可通過(guò)增強(qiáng)骨髓增生活性、調(diào)節(jié)免疫平衡、抑制骨髓細(xì)胞凋亡、阻止骨髓細(xì)胞成脂化、促進(jìn)血管新生、降低炎癥反應(yīng)以促進(jìn)骨髓造血功能恢復(fù)，提高有核細(xì)胞數(shù)量，恢復(fù)血象指標(biāo)水平。總結(jié)了穿龍薯蕷皂苷防治再生障礙性貧血的藥理作用研究進(jìn)展，為穿龍薯蕷皂苷的臨床應(yīng)用提供支持。

Aplastic anemia is a blood immune dysfunction characterized by a decrease in whole blood cells and bone marrow failure, and immunosuppressive therapy is the most commonly used treatment method. Dioscorea nipponica saponins has a structure similar to steroid hormones and has multiple pharmacological effects. Dioscorea nipponica saponins can enhance bone marrow proliferation activity, regulate immune balance, inhibit bone marrow cell apoptosis, prevent bone marrow cell lipidation, promote angiogenesis, reduce inflammatory response to promote bone marrow hematopoietic function recovery, increase the number of nuclear cells, and restore blood count indicators. This article summarizes the pharmacological research progress of Dioscorea nipponica saponins in preventing and treating aplastic anemia, providing support for the clinical application of Dioscorea nipponica saponins.

R977

濟(jì)南市科技局臨床醫(yī)學(xué)科技創(chuàng)新計(jì)劃項(xiàng)目(202004075)