功能性便秘為臨床常見病、多發(fā)病，當(dāng)前治療功能性便秘的藥物主要包括滲透性瀉藥和促進(jìn)胃腸道動力藥，但這些藥物的長期使用或使用不當(dāng)可能引起不良反應(yīng)。中藥活性成分可通過調(diào)節(jié)腸道菌群結(jié)構(gòu)、調(diào)節(jié)胃腸激素水平、促進(jìn)Cajal間質(zhì)細(xì)胞增殖、調(diào)控腸神經(jīng)系統(tǒng)和腸道微環(huán)境、調(diào)控水通道蛋白表達(dá)治療功能性便秘?？偨Y(jié)了中藥活性成分治療功能性便秘的藥理作用研究進(jìn)展，以期為功能性便秘用藥提供參考。

Functional constipation is a common and frequently occurring clinical disease. The current drugs used to treat functional constipation mainly include osmotic laxatives and gastrointestinal motility promoting drugs. However, long-term or improper use of these drugs may cause adverse reactions. The active ingredients in traditional Chinese medicine can treat functional constipation by regulating intestinal flora structure, adjusting gastrointestinal hormone levels, promoting Cajal interstitial cell proliferation, regulating the intestinal nervous system and intestinal microenvironment, and regulating aquaporin expression. This article summarizes the pharmacological research progress of active ingredients in traditional Chinese medicine for the treatment of functional constipation, in order to provide reference for the medication of functional constipation.

R285;R286.5

四川省中醫(yī)藥管理局科學(xué)技術(shù)研究專項(xiàng)項(xiàng)目(2018LC020)