近年來，肺部疾病的發(fā)病率和死亡率呈逐年上升的趨勢，尋找積極有效的治療藥物對減輕肺損傷具有積極意義。桔梗皂苷D是從桔梗中分離出的五環(huán)三萜皂苷，具有多種活性。桔梗皂苷D通過降低肺部炎癥反應、減輕肺部氧化應激反應、抑制肺組織纖維化、阻止肺組織細胞凋亡、阻止病原菌黏附、誘導肺癌腫瘤細胞凋亡、降低肺癌腫瘤細胞的侵襲力發(fā)揮防治肺部疾病作用?？偨Y了桔梗皂苷D防治肺部疾病的研究進展，并歸納其作用機制，為桔梗皂苷D的臨床應用提供支持。

In recent years, the incidence rate and mortality of lung diseases are increasing year by year. It is of positive significance to find active and effective drugs to prevent and treat lung injury. Platycoside D is a pentacyclic triterpenoid saponin isolated from Platycodonis Radix, which has various activities. Platycoside D plays a prevention and treatment role in lung diseases by reducing lung inflammation, alleviating lung oxidative stress, inhibiting lung tissue fibrosis, preventing lung tissue cell apoptosis, inhibiting pathogen adhesion, inducing apoptosis of lung cancer tumor cells, and reducing the invasiveness of lung cancer tumor cells. This article summarizes the research progress on platycoside D in prevention and treatment of lung diseases, summarizes its mechanism of action, and provides support for the clinical application of platycoside D.

R285;R286.4